AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialization of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.
Our Gaithersburg, Maryland facility creates life-changing medicines for people around the world! This campus employs more than 3,500 professionals in our field and is only a short drive from Washington, DC. This modern and vibrant scientific campus is the home of R&D and Oncology in the US. Here, we play host to some of the most cutting-edge technology and lab spaces, all crafted to encourage collaboration and cross-functional science. We believe employees benefit from being challenged and encouraged at work. We are dedicated to crafting a culture of inclusion and collaboration.
The Gaithersburg site offers a variety of amenities to help boost productivity and help keep our employees happy and healthy. This includes a fitness center, employee healthcare clinic, electric vehicle charging stations, dry cleaning, full-service cafeteria and copy center. This is where you’ll find newly-designed, activity-based workspaces to suit a variety of working styles while growing collaboration between teams.
Join a dedicated Oncology team that’s growing fast and building a strong track record of success.
Main Responsibilities
You will work in a laboratory within the Oncology Research group designing, conducting and analyzing in vitro and in vivo experiments to assess the function of our candidate oncology drugs and dissect the mechanism of action of novel therapeutics. You will also review emerging literature and internal data to identify new targets and contribute to target validation activities.
Essential Requirements
Bachelor’s or advanced degree in tumor biology or a related field Depth of understanding for hematology cancer models as well as solid tumor models Experience with a range of in vitro skills for the analysis of human tumor cell function (e.g. cell culture, cell signaling bioassays, high-content imaging, and cell death measurement in primary and cell line cultures) Experience conducting multi-spectral flow cytometry and visualizing/quantitating high content multi-parameter flow data Molecular biology skills including assessment of intracellular signaling and generation of engineered cell lines, generating and/or analyzing transcriptomic data Strong interpersonal and collaboration skills together with evidence of having used these to support problem solving and delivery in a collaborative environment.
Desirable Requirements
Experience in the evaluation of immune function and in the application of complex immunological assays Experience working with cell death modulating agents, with biologics including antibodies and antibody-drug conjugates and evaluation of transcriptomic datasets Familiarity with nano-medicine drug delivery Knowledge of the drug discovery process and publications in credible scientific journals