SCIENTIST - FORMULATION DEVELOPMENT
We are anintegrated genetic medicines company developing targeted, disease-modifyingmedicines for patients with life-limiting respiratory diseases. Our treatmentsaddress the underlying genetic cause in underserved populations and have thepotential to tremendously impact the quality and length of patients’ lives.
At ReCode,we bring a unique blend of rigor, creativity, and curiosity to our high-hurdlemission: harnessing our multi-platform approach to develop disease-modifyingmedicines. Our team is uniquely positioned to tackle this challenge, given ourextensive experience in RNA delivery technologies, protein structure, tRNAbiology, mRNA manufacturing, gene editing, and drug development.
THE ROLE Theincumbent will be responsible for development and optimization of formulationfor lipid nanoparticle / RNA-based product candidates for preclinical andclinical development. In this role the candidate will work with cross-functionalproduct development team including process development and analyticaldevelopment to develop formulations with a good safety profile and high potencyin vitro and in vivo.
HERE’S SOME OF WHAT YOU’LL DO Identify, prepare and analyze novel formulations to support product development. Design experiments to conduct science-based formulation optimization. Evaluate the effect of each formulation component on potency, safety, stability and aerosolization. Summarize results, prepare development reports, and present data to product development team. Partner closely with colleagues conducting formulation evaluations, PK/PD, and in vitro and in vivo studies. Provide formulations expertise and insights to various interdisciplinary teams. Perform formulation transfer to process development teams and provide troubleshooting when needed
HERE’S WHAT YOU’LL BRINGTO THE TABLE
Minimally a Ph.D. in chemistry,bioengineering, chemical engineering, or a related discipline with at least one year of successful laboratory experience in lipid nanoparticles or other lipid-based drugdelivery systems. Comparatively, acandidate possessing an MS in chemistry, bioengineering, chemical engineering,or a related discipline with 6+ years of directly relevant experience will beconsidered. Strong foundation in chemistry, nanotechnologies for formulation design, nucleic acid therapeutics, and general pharmaceutical product research is required. Understanding of the in-vitro and in-vivoexperiments used for screening for candidate formulation required. Experience with process development of complex mixtures a plus. Strong written and oral communication skills. Comfort in a dynamic and fast-paced scientific environment ReCode Therapeutics (www.recodetx.com)offers a competitive compensation/benefits with a friendly, collaborativeculture that values employee engagement and ongoing career development. ReCodeTherapeutics is an Equal Opportunity Employer.