Note: Applications will be accepted until 11:59 PM on the day prior to the Posting End Date above.
Job End Date
Mar 31, 2023
ATTN: APPLICANTS
Please do not apply via the UBC Careers website. To apply, please submit the application to [email protected].
Application made via the UBC website will not be reviewed.
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The Michael Smith Laboratories at the University of British Columbia in Vancouver, Canada, invites applications for a Postdoctoral Fellow (PDF) to join a dynamic team under the supervision of Dr. Sabrina Leslie. The successful candidate will work on a project that applies new biophysical tools to the development of genetic medicines and vaccines. The position is based in a cutting-edge academic research lab and the project will be driven by real and immediate needs, in collaboration with interdisciplinary scientists in the Nanomedicine Center of Excellence (NMIN).
About the high-throughput single-molecule CLiC imaging technology
The Leslie Lab’s single-molecule technology, Convex Lens-induced Confinement (CLiC), works by squeezing molecules into arrays of nanometer- to micrometer-scale “traps” that are large enough to allow the molecules to move and interact freely, but small enough to keep them confined so they can be imaged over extended periods with a high-powered optical microscope. The result is the world’s first tether-free and high-throughput single-molecule technology for analyzing individual molecular interactions in cell-like conditions. CLiC is capable of detecting, following, and understanding rare molecular events – like the drug/target interactions which can ‘silence’ genes associated with the onset of diseases – and by enabling direct visualization of how the drugs work, help us better engineer them.
About the position
The PDF will join a talented, energetic, interdisciplinary team of scientists and engineers working in a newly built laboratory. Our team collaborates with the spin-off company ScopeSys to respond to partnerships with leading drug and vaccine development research groups and companies. The emphasis of this position will be on applications of our single-molecule and single-cell imaging technology to improve and accelerate development of lipid-nanoparticle and RNA-based medicines and vaccines.
This project will require an interdisciplinary skill set, combining physical, chemical and biological expertise. The ideal candidate will possess experience and interest in some of the following areas:
Microscopy of molecules, nanomaterials, cells Instrumentation, optics, engineering Micro/nano-fabrication and lithography Surface science and chemistry DNA, RNA, lipid nanoparticles, cells Biophysical assay and protocol development Electronics, mechanical engineering, machining
The successful candidate will have a PhD and a demonstrated track record in research with first authored peer-review publications. The position will be filled by a well-organized, enthusiastic team player with strong communication skills, who enjoys hands-on lab work and creative trouble-shooting, and who is excited to try new things. Applicants should have a strong interest in building a career in biotechnology and/or nanotechnology research and development, pioneering new biophysical techniques, and commercializing cutting edge science and technology.
Application process
Interested applicants should submit a letter of application that highlights their experience, detailed curriculum vitae including a list of publications, and contact details for 3 references. Application materials should be combined into a single PDF document and sent to [email protected]. Please include “PDF in single-molecule biophysics and biotechnology” in the e-mail subject line. Incorrectly addressed applications will not be considered. Review of applications will begin immediately and continue until the position is filled. We will contact you only if invited for an interview.