Lipidic Nanoparticle Formulation Scientist (req2366)
Posted: 1/14/2022
Location: Frederick, MD
Employee Type: exempt full-time
Job ID: req2366
PROGRAM DESCRIPTION
The Cancer Research Technology Program (CRTP) develops and implements emerging technology, cancer biology expertise and research capabilities to accomplish NCI research objectives. The CRTP is an outward-facing, multi-disciplinary hub purposed to enable the external cancer research community. A major focus of the CRTP is the NCI RAS Initiative with the goal to discover new therapeutic interventions against RAS-driven cancers. In addition, the CRTP hosts the Nanotechnology Characterization Laboratory (NCL) which performs and standardizes preclinical efficacy and toxicity testing of nanoparticles intended for cancer therapeutics and diagnostics, and the Antibody Characterization Lab (ACL) which characterizes monoclonal antibodies or other renewable affinity binding reagents for use in cancer related research. CRTP scientists also work collaboratively with intramural NCI investigators to provide research technologies and expertise.
KEY ROLES/RESPONSIBILITIES
The Nanotechnology Characterization Lab (NCL) provides nanotechnology formulation and characterization services for universities, the pharmaceutical industry and other government programs (http://ncl.cancer.gov). Responsibilities:
Provide support for chemical synthesis, lipidic nanoformulation and scale-up to NCL's formulation customers.
Assist in physicochemical characterization and development of new analytical methods for evaluating nanomedicines.
Present scientific findings in written reports and oral presentations to NCL staff and customers.
BASIC QUALIFICATIONS
To be considered for this position, you must minimally meet the knowledge, skills, and abilities listed below:
Possession of a Doctoral degree from an accredited college/university according to the Council for Higher Education Accreditation (CHEA) in pharmaceutical science, analytical chemistry, medicinal chemistry, biomedical engineering or related discipline. (Additional qualifying experience may be substituted for the required education). Foreign degrees must be evaluated for U.S. equivalency.
In addition to educational requirements, candidates should have had two (2) or more years of competent, innovative research experience beyond doctoral training in a related field of specialty.
Proficiency in developing test or production methods or protocols in an applied area.
Demonstrated ability to manage a production operation or a segment of a specialized service area.
Strong background in lipidic nanoparticle/liposome chemistry, as well as in-depth understanding of nanomaterials physicochemical properties and their characterization is required.
Excellent written and oral communication skills.
Record of publication in peer reviewed journals.
Ability to obtain and maintain a security clearance.
PREFERRED QUALIFICATIONS
Candidates with these desired skills will be given preferential consideration:
Familiarity with drug development and the pharmaceutical industry; understanding of CMC for IND/IDE applications; some knowledge of drug metabolism-pharmacokinetics (DMPK).
Experience should include demonstrated synthetic and analytical skills with respect to the formulation of small molecules and macromolecules using nanotechnology-based drug delivery platforms.
Experience with physicochemical characterization of nanoparticles using state-of-the-art instrumentation and methods such as SEC, MALLS/DLS, AFFFF, MS, TEM, NMR, AFM, HPLC, SANS and SAXS.
Experience preparing data summaries and scientific presentations in the form of lectures, posters and manuscripts.
JOB HAZARDS
This position is subject to working with or have potential for exposure to animal(s) and/or animal material(s).
This position is subject to working with or have potential for exposure to infectious material, requiring medical clearance and immunizations.
This position is subject to working with radioactive material and requires to become an approved radiation worker.