Senior Scientist, siRNA Nanomedicines
At AstraZeneca, we win through science, it’s at the heart of our every success. That science is only possible when we all work together – we’ll always make sure you’re clear about how your role is connected to our wider mission to really show what science can do!
The Biologics Engineering & Targeted Delivery group within Oncology R&D seeks a lab based Senior Scientist focusing on generation and characterization of targeted nanoparticles formed with peptides, polymers, and/or lipids and siRNA. The Senior Scientist will also contribute to the design of materials, conjugation chemistry, and siRNA to optimize therapeutic activity. Data generated will be organized into an electronic lab notebook and presentations to enable accurate decision making, patent filing, and publication of findings in scientific journals.
Major Duties and Responsibilities
Produce and characterize targeted nanoparticles encapsulating siRNA Optimize bioconjugation reactions for targeting ligand attachment Develop and evaluate nanoparticles for intracellular delivery Evaluate nanoparticle performance in vitro and in vivo Conduct experiments to advance hypothesis-driven science and technology development
Educational Requirements and Qualifications
A Ph.D. in materials engineering, polymers science, chemistry, biomedical engineering, pharmaceutical science, or related field Demonstrated proficiency with materials and nanoparticle characterization using modern chromatography methods, NMR, mass spectrometry, and light scattering Proven materials engineering ability as evidenced by a strong track record of publications, patents, and presentations Highly motivated, attention to detail, ability to think independently, and strong problem-solving skills Hands-on experience with mammalian cell culture and assays associated with measuring mRNA knockdown Proficient laboratory skills, record-keeping, data organization and ability to clearly communicate results Must be able to multi-task and manage multiple projects simultaneously
Desirable for the role:
Experience with a broad range of materials used for nucleic acid delivery Familiar with fluorescence correlation spectroscopy (FCS) measurements Experience with in vivo experiments assessing biodistribution and reporter assays such as IVIS imaging Experience with confocal microscopy, Incucyte, or other fluorescence imaging methods
This position is located in Gaithersburg, MD
The AstraZeneca Gaithersburg campus employs more than 3,500 experts in our field and is only a short drive from Washington, DC. This green, sustainable, modern, vibrant scientific campus is where we host some of the most cutting-edge technology and lab spaces. Newly designed, state of the art research spaces and open seating floor plans are just a couple of ways we work cross functionally and collaboratively.
The Gaithersburg campus also provides an award winning café, free garage parking with electric car charging stations, bike racks, free fitness center to include classed and personal training game rooms, outdoor patio, bocce ball court, arcade games and game tables, recharge Pod’s, library, walking trails, onsite dry cleaning pickup, haircutting service, health and wellness center, starbucks café, and much more!
Benefits:
AstraZeneca is a leading company in the healthcare industry, with a mission to enrich the lives of others. It’s our business to support healthy living, not only for our patients, but also for our employees. Our benefits program is flexible enough to meet employees’ varying needs, offers valuable choices, and is highly competitive.
Why AstraZeneca?
At AstraZeneca when we see an opportunity for change, we seize it and make it happen, because any opportunity no matter how small, can be the start of something big. Delivering life-changing medicines is about being entrepreneurial - finding those moments and recognising their potential. Join us on our journey of building a new kind of organisation to reset expectations of what a bio-pharmaceutical company can be. This means we’re opening new ways to work, pioneering cutting edge methods and bringing unexpected teams together.
Come and join our journey - Apply today!
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