The Investigator will:
Develop and execute experimental bench work to build up neoantigen vaccine and therapeutic mRNA platform Design and execute neoantigen peptide identification and production Design and optimize DNA constructs for in vitro mRNA production, candidate screening and lead selection Design and conduct in vitro and in vivo pharmacology, safety and efficacy studies Collaborate with internal and external collaborators Performing data analyses and delivering data presentation to the scientific team Ensuring maintenance of industry-quality records to provide documentation Contribute to high impact research publications/patent applications and regulatory filings
Qualifications
PhD (+ 5 years) experience in mRNA chemistry/biology; nanomedicine; nucleic acid pharmacology; synthetic nucleic-acid-based vaccines, immunotherapy, oncology or related discipline Deep knowledge in mRNA biology and clinical applications of mRNA therapy Deep knowledge in tumor biology, immunotherapy, and neoantigen vaccinology Hands-on experience in neo-antigen identification and production Hands-on experience with various molecular biology techniques, including DNA/RNA operations, in vitro transcription for mRNA synthesis, quantitative PCR, RT-qPCR, branched DNA assay, ddPCR, expression vector design, NGS, shRNA and miRNA Hands-on experience in mammalian cell cultures, cell-based assays and immunological assays for drug research and development Familiar with and willing to work with rodent tumor models Outstanding problem-solving and troubleshooting skills Must be self-motivated, detail-oriented, organized Must be capable of working independently as well as in a collaborative/group environment Good communication and interpersonal skills Ability to multi-task in a fast-paced work environment Strong commitment to accountability with can-do attitude for completion of projects in accordance with team plans and timelines