The Scientist I, Bioanalytical is responsible for planning and performing scientific experiments that contribute to PTC’s research and drug discovery activities. The incumbent works cross-functionally with internal departments, and external resources as appropriate, as part of PTC’s discovery science project teams.
The Scientist I, Bioanalytical supports adherence to relevant regulatory requirements and company Standard Operating Procedures (SOPs) as appropriate. Job Description:
ESSENTIAL FUNCTIONS
Primary duties/responsibilities:
With guidance from the advisor plans, initiates, directs and executes scientific research and experiments and interprets and communicates results as part of multi-disciplinary team(s). This includes performing analyses of primary research literature.
Perform global multi-omics ( e.g. metabolomic, proteomic, transcriptomic, genomic, etc . ) analyses to aid in elucidating the genotypic and phenotypic heterogeneity of rare diseases.
Create and optimize quantitative biomarker assays using both LC-MS/MS techniques ( i.e. MRM or PRM) and immunoassays ( i.e. MSD, Quanterix, or Ella platforms).
Develop new and improve upon existing sample preparation procedures in biofluids, tissues, and cellular systems to conduct multi-omics analyses from a single specimen.
Integrate and visualize high-density datasets to track changes in dynamic biological systems.
Presents findings internally to cross-functional teams.
May Participate in the development and writing of patent applications
Abides by all safety and regulatory guidelines.
Maintains a detailed laboratory notebook.
Performs other tasks as assigned
Interviews and contributes to the evaluation of candidates.
May provide scientific advice to research leadership on projects and areas of expertise.
Abides by all safety requirements.
Contributes to general lab needs such as:
Equipment maintenance.
Capital equipment purchases.
Troubleshoot
KNOWLEDGE/SKILLS/ABILITIES REQUIRED
* Minimum level of education and years of relevant work experience.
Ph.D. in scientific discipline preferably Analytical Chemistry, Biochemistry, or Systems Biology with 1-2 years’ post-doctoral or Industry experience. Fresh PhD graduates welcome to apply!
* Special knowledge or skills needed and/or licenses or certificates required.
Extensive hands-on experience using mass spectrometry instrumentation ( e.g. Sciex, Bruker, etc.) with various mass analyzers ( i.e. Q-IT, Q-ToF, etc.) for targeted and global biomarker analysis.
Experience quantitating protein biomarkers and RNA/DNA expression using automated “capture/reporter” instruments such as: MSD, Quanterix, Ella, or Nanostring.
Capable of developing isolation, enrichment, and purification strategies for both rare and less stable analytes in multiple biological matrices.
Prior use of statistical and visualization software packages for data processing/reduction strategies, hypothesis testing, and network mapping.
Demonstrate ability to work on complex problems to produce experimental data across one or more projects.
Exercises independent judgement within defined procedures and practices.
Demonstrates technical proficiency, collaboration with others within a fast-paced, matrixed, team environment consisting of internal and external team members.
Possesses detailed and expert knowledge of scientific principles and concepts.
Demonstrate ability to work effectively in a multi-disciplinary team environment.
Proficiency with Microsoft Office preferably MS Excel and MS PowerPoint or similar.
Excellent verbal and written communication and skills.
Analytical thinker with excellent problem-solving skills.
Demonstrates an understanding of the strategic alignment of his/her work with corporate goal(s) and demonstrates the ability to adapt to changing priorities and deadlines.
Excellent planning, organization and time management skills including the ability to support and prioritize multiple projects.
*Special knowledge or skills and/or licenses or certificates preferred.
Detailed knowledge of separation techniques for small and large molecules with applied experience on chromatographic systems in multiple flow regimes ( i.e. micro and nano) is preferred.
Prior use of isotopically labeled workflows ( e.g. SILAC, iTRAQ, etc.) to quantitate multi-omics changes without a priori knowledge is a plus.
* Travel requirements
Up to 10%
*Physical requirements (only note if the job requires physical capacity beyond general office work)
Office/Laboratory based position
**At PTC Therapeutics we are seeking candidates in the United States who are fully vaccinated against COVID-19 or who will be fully vaccinated by the time they begin the position.
EEO Statement:
PTC Therapeutics is an equal opportunity employer. We welcome applications from all individuals, regardless of race, color, national origin, gender, age, physical characteristics, social origin, disability, religion, family status, pregnancy, sexual orientation, gender identity, gender expression, disability, veteran status or any unlawful criterion under applicable law. We are committed to treating all applicants fairly and avoiding discrimination.
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