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Position: Principal Scientist (Discovery & Translational Proteomics)
Location: Cambridge (Alewife), Massachusetts
Position Summary
We are seeking an experienced, talented, highly motivated and detail-oriented Proteomics Researcher with proven track record to join the world class Proteomics group within the Research & Early Development organization at BMS. This is a laboratory based position, reports directly to the Head of Discovery & Translational Proteomics within the Small Molecule Drug Discovery organization. The candidate is expected to work effectively in a highly collaborative matrixed environment and interface with leading scientists in Oncology, Immuno-science, Neuroscience, Cardiovascular, and Fibrosis discovery biology areas, Medicinal Chemistry as well as translational researchers and champion proteomics methodologies / modalities to help solve complex drug discovery & translational research questions. The successful candidate is also expected to bring on board and apply leading edge proteomics methods like “Single Cell Proteomics” to discovery & translational research questions. The candidate is expected to spend at least 60% of their time performing proteomics experiments alongside their team as well as interface with the larger proteomics team.
Key Responsibilities
The candidate needs to have good understanding of biochemistry and biology to help articulate the problem statement, communicate with key stakeholders and bridge across matrixed teams.
A demonstrated ability to convert datasets to usable knowledge and utilize it to answer complex biological questions across the Drug Discovery Translational Research continuum.
An established track record and significant experience in articulating the need for proteomics as well as successfully applying proteomics to discovery, translational, clinical discovery space.
Deep experience developing, deploying and utilizing innovative proteomics techniques / workflows to characterize complex proteomes (including post-translational proteomes) to enable discovery, translational and/or clinical research activities is absolutely necessary.
Significant hands-on experience with developing, optimizing and applying next-generation proteomics and protein mass spectrometry methods such as DIA/SWATH, DDA, label free profiling, TMT, MRM, PRM to name a few. Demonstrated ability to develop innovative mass spectrometry based methods for deep unbiased / targeted proteome level analyses.
Experience with proteome level post-translational modification analyses (e.g. glycosylation, acetylation/methylation) is highly desirable.
Deep “hands on” experience with proteomics analytical instrumentation (latest generation, nano-chromatography and mass spectrometry), associated workflows, and data processing software packages is a must.
Experience with proteomics workflows automation from sample preparation to nano-LC/MS and laboratory instrument data management is highly desirable.
Experience and in-depth knowledge of proteomics design of experiments, LC/MS proteomics data processing and subsequent data analyses. Detailed understanding of proteomics related bioinformatics and associated software packages is required.
Experience and ability to successfully interface with bioinformaticians and biostatisticians is a must to enable in-depth proteomics data analysis and achieve superlative outcomes for programs.
Computational skills and basic understanding of biostatistics and programming is desirable.
Familiarity with other “omics” and some experience in building synergies to achieve integrative omics outcomes would be a plus.
Proficiency in applying classical protein biochemical techniques (protein fractionations, chromatography etc.) and most up to date proteomics techniques is expected and familiarity with basic cell culture techniques and standard molecular biology techniques is highly desirable.
Additionally, experience with handling human as well as animal biomatrices (including tissues, plasma …) is highly desirable.
Overall, excellent lab skills and lab etiquette are crucial and required to be successful in this position.
The candidate must have expertise with compiling and reviewing lab work practices and maintain regular scientific records in terms of laboratory notebooks.
The candidate should be proficient with workplace software tools (word processing, excel, presentation etc.).
Qualifications & Experience
Ph.D. (minimum of 4-8 yrs relevant proteomics experience) in Analytical Chemistry, Biochemistry, Life Sciences, or related field is preferred.
Scientific creativity, innovation and resilience are absolutely necessary to be successful in this position.
A track record of scientific productivity in proteomics area documented in high impact peer reviewed journals is necessary.
A demonstrated ability to manage teams and contribute strategically to areas of discovery & translational research.
The candidate should have a strong interest in drug discovery, translational, and clinical research.
The individual should possess ability to handle multiple projects in parallel, closely collaborate & matrix with scientists within the group and with investigators across Research and Early Development organization.
The candidate is required to have effective organization and presentation skills; be reliable, highly motivated, have strong interpersonal communication skills and embrace working in a team/matrix environment.
Ability to effectively manage scientific staff by articulating a vision, prioritizing work and supervising studies is highly desirable.
The candidate should possess strong personal attributes of integrity, perseverance in face of challenges, and ability to tackle highly complex challenges.
Around the world, we are passionate about making an impact on the lives of patients with serious diseases. Empowered to apply our individual talents and diverse perspectives in an inclusive culture, our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
Bristol Myers Squibb recognizes the importance of balance and flexibility in our work environment. We offer a wide variety of competitive benefits, services and programs that provide our employees with the resources to pursue their goals, both at work and in their personal lives.
Physical presence at the BMS worksite or physical presence in the field is an essential job function of this role which the Company deems critical to collaboration, innovation, productivity, employee well-being and engagement, and enhances the Company culture.
To protect the safety of our workforce, customers, patients and communities, the policy of the Company requires all employees and workers in the U.S. and Puerto Rico to be fully vaccinated against COVID-19, unless they have received an exception based on an approved request for a medical or religious reasonable accommodation. Therefore, all BMS applicants seeking a role located in the U.S. and Puerto Rico must confirm that they have already received or are willing to receive the full COVID-19 vaccination by their start date as a qualification of the role and condition of employment. This requirement is subject to state and local law restrictions and may not be applicable to employees working in certain jurisdictions such as Montana. This requirement is also subject to discussions with collective bargaining representatives in the U.S.
Our company is committed to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace adjustments and ongoing support in their roles. Applicants can request an approval of accommodation prior to accepting a job offer. If you require reasonable accommodation in completing this application or if you are applying to a role based in the U.S. or Puerto Rico and you believe that you are unable to receive a COVID-19 vaccine due to a medical condition or sincerely held religious belief, during or any part of the recruitment process, please direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.
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