Position Summary:
The Zoetis pharmacokinetics, pharmacodynamics, metabolism group (PDM) is recruiting a talented scientist to join our team to discover novel therapeutics for veterinary medicine. This position will require a highly motivated and independent scientist who can effectively collaborate with other team members to advance projects. Specifically, we are looking for a scientist to join our PDM team focusing on the quantification of small molecule and large molecule therapeutics and the development of biomarker assays.
Responsibilities:
Independent hands-on development and fit-for-purpose qualification of LC-MS methods to quantify small molecule and large molecule therapeutics and biomarkers in biological matrices such as serum, tissue, and cell culture. Implement appropriate separation and detection strategies to support drug discovery/development programs. Work with project teams and study directors to provide assay support to studies within agreed upon timelines. Prepare reports and present results to scientific teams and management. Participate/lead continuous improvement and innovation efforts within the PDM bioanalytical group.
Basic Qualifications:
Ph.D (0 - 2 years of relevant experience), M.S. (with 3+ years of relevant experience), or B.S. (with 5+ years of relevant experience) in chemistry, biochemistry, or related field, with hands-on experience using mass spectrometry techniques to characterize and quantify small and large molecule therapeutics and biomarkers. Exhibits enthusiasm for analytical chemistry and has a high degree of attention to detail. Ability to work effectively as both an individual contributor and in a collaborative team setting. Track record of successfully troubleshooting issues that arise during bioanalytical assay development, qualification, validation, and sample analysis. Understanding of quality expectations and regulatory guidance around LC-MS therapeutic and fit-for-purpose (FFP) biomarker assay development and validation. Demonstrated ability to develop, optimize, and FFP validate LC-MS methods for quantitative analysis of analytes in biological matrices (serum, tissue, cell culture). Experience with the proper handling and storage of therapeutic and biomarker biological samples and associated critical reagents. Excellent written and oral communication skills.
Desired Skill Sets:
Experience with the operation and maintenance of Sciex, Waters, and/or Thermo triple quadrupole mass spectrometers. Experience with the operation and maintenance of Thermo, Waters, and/or Bruker high resolution mass spectrometry platforms Experience with small molecule extraction techniques and basic/advanced large molecule extraction techniques for both biological fluid and tissue matrixes. Familiarity and experience with hybrid-LBA-LCMS assay workflows. Experience with laboratory automation for sample extraction workflows. Experience with conventional-flow and low-flow (nano, capillary) chromatography equipment including use of multiple inline columns to enrich and separate analytes of interest. Familiarity with ligand binding assays (e.g. ELISAs) on various platforms such as MSD or Gyrolab. Familiarity with characterization of proteins (e.g. gel electrophoresis, HPLC-size exclusion chromatography, etc.) Experienced with LIMS and PK software, such as Watson, and others. Full time Regular Colleague Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at [email protected] to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of “@zoetis.com”. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.