DMPK Senior Scientist / Associate Principal Scientist
Permanent Opportunity
Location: Cambridge, UK
Do you have expertise in DMPK, and a particular strength for in-vitro ADME Science or Met-ID and biotransformation?
Would you like to apply your expertise to impact the lives of patients in a company that follows the science and turns ideas into life changing medicines? Then AstraZeneca might offer your next career move!
ABOUT ASTRAZENECA
AstraZeneca is a global, science-led, patient-focused biopharmaceutical company that focuses on the discovery, development and commercialisation of prescription medicines for some of the world’s most serious diseases. But we’re more than one of the world’s leading pharmaceutical companies.
A place built on courage, curiosity and collaboration – we make bold decisions driven by patient outcomes. Empowered to lead at every level, free to ask questions and take smart risks that write the next chapter for our pipeline and Oncology team.
Site Description
Welcome to Cambridge, one of over 400 sites here at AstraZeneca, providing a collaborative environment where everyone feels comfortable and able to be themselves is at the core of AstraZeneca’s priorities, it’s important to us that you bring your full self to work every day. To help you maintain your best self, here’s a sneak peek into some of the things this site provides for you…
Where life meets Science…Chesterford Research Park offers advanced laboratory and office space set within 250 acres of idyllic parkland near Cambridge – modern, dynamic, flexible facilities perfectly appointed for biotechnology, pharmaceutical and R&D companies. You will have access to a stylish, fully air conditioned health and fitness centre, an onsite restaurant, Lunch & Learn development activities, all within a spacious environment while utilising the most advanced technology.
This role will then relocate to the Cambridge Biomedical Campus, this site combines world-class biomedical research, patient care and education on a single site location in the heart of Cambridge. This new purpose-built site will bring together the company’s research and development activity in a pioneering strategic R&D centre and global corporate headquarters. The building has been designed with the open architecture reflecting AstraZeneca’s collaborative approach to research. Open laboratories and transparent glass walls will enable new ways of working across disciplines, whilst a central courtyard will put science on full display!
BUSINESS AREA
Oncology R&D is a major focus area and growth platform at AstraZeneca. Our vision is to be at the forefront of developing the new generation of cancer therapies. We work together across all boundaries to have a positive impact in the world by solving complicated problems.
Be part of fulfilling our ambition to be world leaders in Oncology. We are already the fastest growing team within AstraZeneca and across the industry, and there are countless new indications and targets in our game-changing pipeline.
The vision of AstraZeneca Oncology is to redefine cancer, redefine our solutions to cancer, and restore patients' lives. To achieve this, we have an exciting and diverse portfolio that focuses on four scientific platforms that we believe show the greatest potential for yielding effective medicines for cancer patients. These scientific platforms include; Immuno-Oncology (IO), Tumor Drivers & Resistance (TDR), DNA Damage Response (DDR) and we are developing therapeutic agents across multiple modalities including; small molecules, biologics, Antibody Drug Conjugates (ADCs), nano-medicines and PROTACs.
The Oncology Drug Metabolism and Pharmacokinetics (DMPK) department provides ADME/PK, as well as translational PK/PD Modelling & Simulation support to our discovery and development portfolio. We are looking for an experienced DMPK scientist who has a passion for in-vitro ADME and / or biotransformation sciences and the experience and expertise to champion and develop these scientific areas.
In this role you will provide disciplinary scientific leadership in collaboration with the DMPK project leaders to AZ oncology drug discovery and development projects. You will exercise matrix leadership and tutor junior scientists by providing expert advice and context for the interpretation of complex data. Functional representation on oncology drug discovery projects is a development opportunity of the role. The position is based in Cambridge UK.
What you’ll do
Accountabilities
Devising and conducting bespoke ADME and / or biotransformation experimental science to support oncology portfolio projects (multiple modalities). Delivering analytical & in-vitro solutions for challenging small molecules including beyond rule of five compounds. Recommending and leading innovations within the discipline Providing disciplinary scientific leadership for less experienced scientists Publishing papers in internationally recognised journals Contributing to discipline review groups Supporting the department’s leadership team in both the strategic vision and operational effectiveness
Minimum Requirements – Education, Experience and Capabilities
The ideal candidate should have a Ph. D. degree or corresponding experience in a relevant scientific discipline, with several years of experience in drug discovery and/or early development or alternatively a first degree and extensive relevant additional experience in drug discovery and early development.
Extensive experience and expertise in several of the following:
Experimental determination of in-vitro ADME properties e.g. metabolic clearance, potential for drug-drug-interactions, permeability or transporter properties Designing, conducting and evaluating studies to identify metabolites of drug candidates (in-vitro / in-vivo) and devising biotransformation pathways Experience of LC-MS/MS method development and problem solving for quantitative bioanalysis Development, validation and improvement of in-vitro ADME assays Understanding of correlations between phys-chem and in-vitro ADME properties and in-vivo PK behaviour of compounds. Broad understanding of all DMPK needed to support drug discovery and / or development projects Scientific publication track record in in-vitro ADME and / or biotransformation sciences Excellent interpersonal skills that lead to successful collaborative work-relationships is a must have
Additional details
No direct line reports, but there is an expectation to mentor junior scientists and opportunities to supervise students and interns or PhDs to pursue scientific projects.
Why AstraZeneca?
At AstraZeneca we’re dedicated to being a Great Place to Work. Where you are empowered to push the boundaries of science and unleash your entrepreneurial spirit. There’s no better place to make a difference to medicine, patients and society. An inclusive culture that champions diversity and collaboration, and always committed to lifelong learning, growth and development. We’re on an exciting journey to pioneer the future of healthcare!
So, what’s next?
Are you already imagining yourself joining our team? Good, because we can’t wait to hear from you.
Competitive salary and benefits package on offer.
This includes a flexible benefits package, private healthcare, performance bonus, travel discount schemes to support commuting costs etc.
Closing date: 25th February 2022
Where can I find out more?
Connect with our recruiter on LinkedIn: Sam Hunter https://www.linkedin.com/in/samhunter1/
Our Social Media, Follow AstraZeneca on LinkedIn https://www.linkedin.com/company/1603/
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