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Research Officer Proteomics, Mass Spectrometry

Research Officer Proteomics, Mass Spectrometry


Make an important contribution to the health of children through medical research Work with one of Australia’s most respected national and independent medical research institutes Gain valuable experience in the not-for-profit sector
Children’s Medical Research Institute (CMRI) was Australia’s first dedicated paediatric
research facility and is now one of the nation’s most highly regarded independent medical
research centres. Our research focuses on the areas of cancer, neuroscience, embryonic
development and birth defects, and gene therapy and we have a strong international
reputation based on our research outcomes. CMRI’s research programs are supported by
state of the art facilities and committed research and support staff. Our achievements are
made possible by a loyal network of community supporters, highly engaged donors and
the very successful Jeans for Genes® fundraising campaign.

The ACRF International Centre for the Proteome of Cancer (ProCan), located at CMRI, is
using innovative technology to rapidly measure the precise levels of many thousands of
proteins simultaneously in very small cancer samples. Led by CMRI's Professor Phil
Robinson and Professor Roger Reddel, the Centre continues to analyse up to 70,000
cancer samples of all types. Advanced computer analysis techniques are being used to
compare the protein data with the information that is already available about the cancer,
including pathology test results, response of the tumours to cancer treatments and other
available omic data. This is being used assist oncologists to make a more precise
diagnosis of the cancer type and its molecular subtype, and to provide each cancer
patient's doctors with a list of the treatment options to which the cancer is most likely to
respond.

We are seeking a highly motivated PhD level Research Officer to join the ProCan team at
CMRI to support sample collection, preparation, running and analysis of samples.

The ideal candidate will have expertise in proteomics sample preparation with a strong
analytical background. Hands-on experience with proteomic sample preparation, mass
spectrometry (MS) and liquid chromatography (LC) instrumentation is essential. This
includes the design and execution of proteomics experiments including label/ label-free
quantitative experiments. The appointee will also be required to troubleshoot MS, nano-
and regular flow HPLC as well as perform instrument maintenance.



The successful candidate must address the following criteria:
PhD in Biochemistry, Biotechnology or equivalent experience in a related field. Minimum of 3 years hands-on LC-MS/MS experience, and strong troubleshooting

abilities.


Experience in training scientists in the field of proteomics. Strong knowledge of proteomic sample preparation and purification and enrichment techniques.
Experience in quantitative label-based and label-free MS techniques (e.g. iTRAQ, TMT, DIA/SWATH) an advantage.
Experience with standard database search algorithms and data analysis tools such as DIA-NN, Syline, OneOmics, MaxQuant, MASCOT, Scaffold, and
ProteinPilot.
Experience with SRM/MRM or PRM method development and analysis would be advantageous.
Experience with PTMs such as phosphorylation is desirable, but not essential. Fractionation of peptides using HPLC, specifically high pH RP-HPLC, is desirable.
Proficiency in handling large-data-sets including basic bioinformatics and biostatistics skills.
Experience coding in python or R is an advantage. Experience with the management of commercially sensitive information. Experience in a PC2 facility is essential, while experience in a proteomics core facility or proteomics laboratory environment is desirable.
Previous applicants to any ProCan positions in the last 12 months need not re-

apply.

The position is for 3 years, subject to funding, and salary levels are dependent on the
candidates’ skills and experience. Additional benefits include the provision of a Public
Benevolent Institution salary packaging scheme and participation in an employer-
contributed superannuation fund.

Applications should include a cover letter (citing PV2208), curriculum vitae and contact
details (phone/email) of three professional referees and be forwarded to
[email protected]

We will interview suitable candidates as applications are received. Closing date for
applications is noon 28th February 2022.



Research Officer Proteomics, Mass Spectrometry


Make an important contribution to the health of children through medical research Work with one of Australia’s most respected national and independent medical research institutes Gain valuable experience in the not-for-profit sector
Children’s Medical Research Institute (CMRI) was Australia’s first dedicated paediatric
research facility and is now one of the nation’s most highly regarded independent medical
research centres. Our research focuses on the areas of cancer, neuroscience, embryonic
development and birth defects, and gene therapy and we have a strong international
reputation based on our research outcomes. CMRI’s research programs are supported by
state of the art facilities and committed research and support staff. Our achievements are
made possible by a loyal network of community supporters, highly engaged donors and
the very successful Jeans for Genes® fundraising campaign.

The ACRF International Centre for the Proteome of Cancer (ProCan), located at CMRI, is
using innovative technology to rapidly measure the precise levels of many thousands of
proteins simultaneously in very small cancer samples. Led by CMRI's Professor Phil
Robinson and Professor Roger Reddel, the Centre continues to analyse up to 70,000
cancer samples of all types. Advanced computer analysis techniques are being used to
compare the protein data with the information that is already available about the cancer,
including pathology test results, response of the tumours to cancer treatments and other
available omic data. This is being used assist oncologists to make a more precise
diagnosis of the cancer type and its molecular subtype, and to provide each cancer
patient's doctors with a list of the treatment options to which the cancer is most likely to
respond.

We are seeking a highly motivated PhD level Research Officer to join the ProCan team at
CMRI to support sample collection, preparation, running and analysis of samples.

The ideal candidate will have expertise in proteomics sample preparation with a strong
analytical background. Hands-on experience with proteomic sample preparation, mass
spectrometry (MS) and liquid chromatography (LC) instrumentation is essential. This
includes the design and execution of proteomics experiments including label/ label-free
quantitative experiments. The appointee will also be required to troubleshoot MS, nano-
and regular flow HPLC as well as perform instrument maintenance.



The successful candidate must address the following criteria:
PhD in Biochemistry, Biotechnology or equivalent experience in a related field. Minimum of 3 years hands-on LC-MS/MS experience, and strong troubleshooting

abilities.


Experience in training scientists in the field of proteomics. Strong knowledge of proteomic sample preparation and purification and enrichment techniques.
Experience in quantitative label-based and label-free MS techniques (e.g. iTRAQ, TMT, DIA/SWATH) an advantage.
Experience with standard database search algorithms and data analysis tools such as DIA-NN, Syline, OneOmics, MaxQuant, MASCOT, Scaffold, and
ProteinPilot.
Experience with SRM/MRM or PRM method development and analysis would be advantageous.
Experience with PTMs such as phosphorylation is desirable, but not essential. Fractionation of peptides using HPLC, specifically high pH RP-HPLC, is desirable.
Proficiency in handling large-data-sets including basic bioinformatics and biostatistics skills.
Experience coding in python or R is an advantage. Experience with the management of commercially sensitive information. Experience in a PC2 facility is essential, while experience in a proteomics core facility or proteomics laboratory environment is desirable.
Previous applicants to any ProCan positions in the last 12 months need not re-

apply.

The position is for 3 years, subject to funding, and salary levels are dependent on the
candidates’ skills and experience. Additional benefits include the provision of a Public
Benevolent Institution salary packaging scheme and participation in an employer-
contributed superannuation fund.

Applications should include a cover letter (citing PV2208), curriculum vitae and contact
details (phone/email) of three professional referees and be forwarded to
[email protected]

We will interview suitable candidates as applications are received. Closing date for
applications is noon 28th February 2022.


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