Zouhair Majdi BACCAR

NanoBioengineering
National Institute of Research and Physicochemical Analysis

Interests

My main interests focus on the development of new hybrid nanomaterials Biomolecule / LDH and surface functionalization of capacitive transducers as well as Field Effect.
My research concern the development of layered double hydroxides (LDH) in which we immobilize biomolecules species such as enzymes, antibodies or oligonucleotides. A semiconductor transducer of the biosensor were modified by deposing a thin layer (less than 100nm) of hybrid nanomataterials of for its functionnalization. One of the main complexities of this work lies in the immobilization of bioreceptors without release into the analyte in the storage solution (if necessary) or during regeneration of the biomembrane. In addition, the host matrix must meet the maximum bioreceptors conformation which must remain very close to the biomolecule and free, in order to preserve maximum catalytic and physicochemical properties and thus produce highly sensitive biosensors. Finally, the choice of LDH is crucial to ensure both an optimal anchor bioreceptors but also surface functionalization of transducer-based semi-conductor by depositing a thin layer self-assembled uniform and adheres strongly to the oxide insulator.

Projects

PI of :
6 Spanish-Tunisian (AECI and AECID) for developing biosensor based on hybrid nanomaterials for long probe of DNA, fibrosis cystic diagnosis, histamine and toxin in mollusk monitoring,
1 Morocco-Tunisian (CMPTM) program on development of biosensors for milk quality monitoring.

Publications

1. Bassam Alfeeli, Mamoun Al-Rawashdeh, Ali Bumajdad, Haider Al Lawati, Mohamed Abdelgawad, Zouhair Baccar, Issam Ben Salem, Faysal Benaskar. "A Review of Nanotechnology Development in the Arab World". Nanotechnology Reviews, Vol2 (3) (2013) 359-377.
2. Z.M. Baccar, D. Caballero, R. Eritja, A. Errachid. "Development of an Impedimetric DNA-Biosensor Based on Layered Double Hydroxide for the Detection of Long ssDNA sequences". Electrochimica Acta, Vol 74 (2012) 123-129
3. Z.M. Baccar, S. Hidouri, A. Errachid, O. Ruiz-Sanchez.
«Study of bi-enzyme immobilization onto LDH nanomaterials for histamine biosensor application» J. Nanosci. Nanotechnol., Vol.11 (2011), 8798-8803.
4. S. Hidouri, Z.M. Baccar, H. Abdelmelek, T. Noguer, J.-L. Marty and M. Campàs.
«Structural and functional characterisation of a biohybrid material based on acetylcholinesterase and layered double hydroxides», Talanta. Vol. 85 (2011) 1882-1887
5. Z.M. Baccar, I. Hafaiedh
« Immobilization of HRP Enzyme on layered double hydroxides for Biosensor Application» International Journal of Electrochemistry (2011) doi:10.4061/2011/934893
6. Z. M. Baccar, D. Caballero, N. Zine, N. Jaffrezic-Renault, and A. Errachid
« Development of Urease/Layered Double Hydroxides Nanohybrid Materials for the Urea Detection: Synthesis, Analytical and Catalytic Characterizations», Sensor lett., 7 (2009), 647-655
7. Z. M. Baccar, S. Hidouri, N. El Bari, N. Jaffrezic-Renault, A. Errachid, and N. Zine
« Stable Immobilization of Anti-Beta Casein Antibody onto Layered Double Hydroxides Materials for Biosensor Applications», Sensor lett., 7 (2009), 676-682
8. Z.M. Baccar, N. Jaffrezic-Renault, C. Martelet, H. Jaffrezic, G. Marest, A. Plantier
« New fluoride sensitive membranes prepared through an ion implantation process », J. Mater. Sci., Vol.32, N°16 (1997), 4221-4225.
9. Z.M. Baccar, M. Lemiti, N. Jaffrezic-Renault
« Aminated membranes for pH detection obtained by photo-CVD technique ». J. Electrochem. Soc., Vol.144, 11 (1997), 3989-3992.
10. Z.M. Baccar, N. Jaffrezic-Renault, E. Fourmond, M. Lemiti, F.F. Grekov
« Influence of the aminated conditions on the pH sensitivity of silica and amorphous silicon film ». Journal of European Ceramic Society, 17 (1997), 2021-2024.
11. Z.M. Baccar, N. Jaffrezic-Renault, C. Martelet, H. Jaffrezic, G. Marest, A. Plantier
« K+ ISFET type micro sensors fabricated by ion implantation ». Materials Chemistry and Physics, 48 (1997), 56-59.
12. Z.M. Baccar, N. Jaffrezic-Renault, C. Martelet, H. Jaffrezic, G. Marest, A. Plantier
« Sodium microsensors based on ISFET/REFET prepared through an ion implantation process fully compatible with a standard silicon technology ». Sensors & Actuators B 32 (1996), 101-105.
13. Z.M. Baccar, N. Jaffrezic-Renault, J.M. Krafft, C. Martelet, H. Jaffrezic, G. Marest, A. Plantier
« Characterization of Na+sensitive EOS Structures Obtained by Ion Implantation Technique ». J. Electrochem. Soc, Vol.143, 4 (1996), 1422-1426.