Publications
Ai H, Pink JJ, Shuai X, Boothman DA, Gao J. Interactions between self-assembled polyelectrolyte shells and tumor cells. 2005; J. Biomedical Material Research 73:303-312.
Araki S, Israel S, Leskov KS, Criswell TL, Beman M., Klokov DY, Sampath L, Reinicke KE, Cataldo, E, Mayo LD, Boothman DA. Clusterin proteins: stress-inducible polypeptides with proposed functions in multiple organ dysfunction. 2005; British Journal of Radiology 27:106-113.
Bentle M, Reinicke K, Bey E, Spitz D, Boothman DA. Calcium regulation of PARP-1 hyperactivation for altered cellular metabolism and inhibition of DNA repair. 2006; J Biological Chemistry 281:33684-33696.
Nasongkla N, Bey E, Ren J, Khemtong C, Setti-Guthi J, Chin S-F, Sherry AD, Boothman DA, Gao, J. Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems. 2006; Nano Letters 6:2427-2330.
Wang F, Blanco E, Ai H, Boothman DA, Gao, J. Modulating ß-lapachone release from polymer millirods through cyclodextrin complexation. 2006; J. Pharm Sci. 95:2309-2319.
Shannan B, Seifert M, Leskov K, Willis J, Boothman DA, Tilgen W, Reichrath, J. Challenge and promise: roles for clusterin in pathogenesis, progression and therapy of cancer. 2006; Cell Death and Differentiation (CDD) 13:12-19.
Shannan B, Seifert M, Leskov K, Boothman DA, Pfohler, C, Tilgen, W, Reichrath, J. Clusterin (CLU) and melanoma growth: CLU is expressed in malignant melanoma and 1,25-dihydroxyvitamin D3 modulates expression of CLU in melanoma cell lines in vitro. 2006; Anticancer Res. 26:1498-1504.
Shannan B, Seifert M, Boothman DA, Tilgen W, Reichrath J. Clusterin over-expression modulates proapoptotic and antiproliferative effects of 1,25(OH)(2)D(3) in prostate cancer cells in vitro. 2007; J. Steroid Biochemistry and Molecular Biology 103: 721-725.
Bey EA, Bentle MS, Reinicke KE, Dong Y, Yang CR, Girard L, Minna JD, Bornmann WG, Gao J, Boothman DA. An NQO1-and PARP-1-mediated cell death pathway induced in non-small-cell lung cancer cells by beta-lapachone. 2007; Proc Natl Acad Sci, USA 104:11832-11837. PMCID: PMC1913860.
Choi EK, Terai K, Ji I-M, Kook Y, Park K, Oh E, Griffin R, Lim B, Lee D, Boothman DA, Loren M, Song CW, Park HJ. Radiation-induced up-regulation of NAD(P)H:quinone oxidoreductase (NQO1) potentiates the effect of bioreductive ß-lapachone against cancer cells. 2007; Neoplasia 9:634-642. PMCID: PMC1950433.
Bentle MS, Reinicke KE, Dong Y, Bey EA, Boothman DA. Non-homologous end joining is essential for cellular resistance to beta-lapachone. 2007; Cancer Research 67:6936-6945. PMID: 17638905.
Blanco E, Bey EA, Dong Y, Weinberg BD, Sutton DS, Boothman DA, Gao J. Beta-lapachone-containing PEG-PLA polymer micelles as novel nanotherapeutics against NQO1-overexpressing tumor cells. 2007; J. Control Release 122:365-374. PMCID: PMC2064869
Gomez J, Gama V, Yoshida T, Sun W, Hayes P, Leskov K, Boothman DA, Matsuyama S. Bax-inhibiting peptides derived from Ku70 and cell-penetrating pentapeptides. 2007; Biochem. Soc. Trans. 53:797-801.
Wagner MW, Li LS, Morales JC, Galindo CL, Garner HR, Bornmann WG, and Boothman DA. Role of c-abl in MMR-dependent G2 arrest responses. 2008; J. Biological Chemistry 283:21382-21393. PMCID: PMC2490779.
Li LS, Morales JC, Hwang A, Wagner MW, Boothman DA. DNA mismatch repair-dependent activation of c-Abl/p73a/GADD45a-mediated apoptosis. 2008; J. Biological Chemistry 283:21394-21403. PMCID: PMC2490771.
Trougakos IP, Lourda M, Antonelou MH, Kletsas D, Gorgoulis VG, Papassideri IS, Zou Y, Margaritis LK, Boothman DA, Gonos ES. Intracellular clusterin inhibits mitochondrial apoptosis by suppressing p53-activating stress signals and stabilizing the cytosolic Ku70-Bax protein complex. 2009; Clinical Cancer Research 15:48-59. PMID: 19118032, PMIC Pending.
Trougakos IP, Djeu, YJ, Gonos ES, Boothman DA. Advances and challenges in basic and translational research on clusterin. 2009; Cancer Research 69:403-406. PMID: 19147550, PMIC Pending.
Ying D, Chin S-F, Blanco E, Bey EA, Kabbani W, Xie X-J, Bornmann WG, Gao J, Boothman DA. Intratumoral delivery of ß-lapachone via polymer implants for prostate cancer therapy. 2009; Clinical Cancer Research 15(1):131-139. PMID: 19118040, PMIC Pending.
Pucci S, Mazzarelli P, Sesti F, Boothman DA, Spagnoli LG. Interleukin-6 affects cell death escaping mechanisms acting on bax-Ku70-clusterin interactions in human colon cancer progression. 2009; Cell Cycle 8(3):1-9. PMID 19177010, PMIC Pending.
Khemtong C, Kessinger CW, Ren J, Bey EA, Boothman DA, Sherry AD, Gao J. Turning “ON” the superparamagnetic nanoprobes for cancer molecular imaging. 2009; Cancer Research, 69(4):1651-1658. PMID: 19190328, PMIC Pending.
Park S, Hatanpaa KJ, Xie Y, Mickey BE, Madden CJ, Raisanen JM, Ramnarain DB, Xiao G, Saha D, Boothman DA, Zhao D, Bachoo RM, Pieper RO, Habib AA. The receptor interacting protein (RIP1) inhbits p53 induction through NF-kB activation and confers a worse prognosis in glioblastoma. 2009; Cancer Research 69(7):2809-2816. PMID 19339267. PMIC pending.
Mukherjee B, McEllin B, Camacho CV, Tomimatsu N, Sirasanagandala S, Nannepaga S, Hatanpaa HJ, Mickey B, Madden C, Elizabeth Maher E, Boothman DA, Furnari F, Cavenee WK, Bachoo RM, Burma S. EGFRvIII and DNA Double-Strand Break Repair: A Molecular Mechanism for Radioresistance in Glioblastoma. 2009; Cancer Research 69(10):4252-4259. PMID 19435898, PMIC pending.
Park S, Zhao D, Hatanpaa KJ, Mickey BJ, Saha D, Boothman DA, Story MD, Wong ET, Burma S, Georgescu MM, Rangnekar V, Chauncey SS, Habib AA. RIP1 activates PI3K-Akt via a dual mechanism involving NF-kappaB mediated inhibition of the mTOR-S6K-IRS1 negative feedback loop and downregulation of PTEN. 2009; Cancer Research 69(10): 4107-4115. PMID 19435890, PMIC pending.
Konstantinidou G, Bey EA, Rabellino A, Schuster K, Maira MS, Gazdar AF, Amici A, Boothman DA, Scaglioni PP. Dual phosphoinositide 3-kinase/mammalian target of rapamycin blockade is an effective radiosensitizing strategy for the treatment of non-small cell lung cancer harboring K-RAS mutations. 2009; Cancer Research 69(19):7644-7652. PMID: 19789349; PMIC Pending.
Markopoulou S, Kontargiris E, Batsi C, Tzavaras T, Trougakos I, Boothman DA, Gonos E, Kolettas, E. Vanadium-induced apoptosis of HaCaT cells is mediated by c-fos and involves nuclear accumulation of clusterin. 2009; FEBS Letters 276(14):3784-3799. PMID 19531052, PMIC pending.
Araki S, Eitel JA, Batuello CN, Bijangi-Vishehsaraei K, Xie XJ, Danielpour, D, Pollok KE, Mayo LD, Boothman DA. TGF-beta1-induced expression of human Mdm2 correlates with late-stage metastatic breast cancer. 2010; J. Clinical Investigation, 120(1): 290-302. PMID 19955655, PMIC pending.
Dong Y, Bey EA, Li L, Kabbani W, Yan J, Xie X-J, Hsieh JT, Gao J, and Boothman DA. Prostate cancer radiosensitization through poly(ADP-ribose) polymerase-1 hyperactivation. 2010; Cancer Research, 70(20): 8088-8096.
Li LS, Bey, EA, Ying Dong Y, Meng, J, Patra B, Yan J, Xian-Jin Xie X-J, Brekken, RA, Barnett, CA, William G. Bornmann WG, Gao J, and Boothman DA. Modulating endogenous NQO1 levels identifies key regulatory mechanisms of action of ß-lapachone for pancreatic cancer therapy. 2011; Clinical Cancer Research 17(2): 275-285.
