Publications
Lappano, R., Santolla, M.F., Pupo, M., Sinicropi, M.S., Caruso, A., Rosano, C., Maggiolini, M. (2012). MIBE acts as antagonist ligand of both estrogen receptor alpha and GPER in breast cancer cells. Breast Cancer Res 14(1):R12.
Stec-Martyna, E, Ponassi, M Miele, M, Parodi, S Felli, L, Rosano, C. (2012). Structural Comparison of the Interaction of Tubulin with Various Ligands Affecting Microtubule Dynamics. Current Cancer Drug Targets 12(6):658-66.
Lappano, R., Rosano, C., Santolla, M.F., Pupo, M., De Francesco, E..F., De Marco, P., Ponassi, M., Spallarossa, A., Ranise, A., Maggiolini, M. (2012). Two novel GPER agonists induce gene expression changes and growth effects in cancer cells. Current Cancer Drug Targets. 12(5):531-42.
Pupo M., Pisano, A., Lappano, R., Santolla, M.F., De Francesco, E.F. Rosano, C., Maggiolini, M. (2012). Bisphenol A induces gene expression changes and proliferative effects through GPER in breast cancer cells and cancer-associated fibroblasts. Environmental Health Perspectives.120(8):1177-82
Paciotti, S., Persichetti, E., Pagliardini, S., Deganuto, M., Rosano, C., Balducci, C., Codini, M., Filocamo, M., Menghini. A.R., Pagliardini, V., Pasqui, S., Bembi, B., Dardis, A., Beccari, T. (2012) First pilot newborn screening for four lysosomal storage diseases in an Italian region: Identification and analysis of a putative causative mutation in the GBA gene. Clin Chim Acta. Jul 18. 413(23-24):1827-31
Zampieri S, Cattarossi S, Oller Ramirez AM, Rosano C, Lourenco CM, Passon N, Moroni I, Uziel G, Pettinari A, Stanzial F, de Kremer RD, Azar NB, Hazan F, Filocamo M, Bembi B, Dardis A. (2012) Sequence and Copy Number Analyses of HEXB Gene in Patients Affected by Sandhoff Disease: Functional Characterization of 9 Novel Sequence Variants. PLoS One. 7(7):e41516.
Piccinin ,S., Tonin, E., Sessa, S., Demontis, S., Rossi, S., Pecciarini, L., Zanatta, L., Pivetta, F., Grizzo, A., Sonego, M., Rosano, C., Dei Tos, A.P., Doglioni, C., Maestro, R. (2012) A "Twist box" Code of p53 Inactivation: Twist box:p53 Interaction Promotes p53 Degradation. Cancer Cell ;22(3):404-15.
Abbassi, N., Chicha, H., Rakib, E.M., Hannioui, A., Alaoui M., Hajjaji A., Geffken, D., Aiello, C., Gangemi, R., Rosano, C., Viale, M. (2012). Synthesis, antiproliferative and apoptotic activities of N-(6(4)-indazolyl)-benzenesulfonamide derivatives as potential anticancer agents. Eur. J. Med. Chem. 57C:240-249
Rosano C., Lappano R., Santolla M.F., Ponassi M., Donadini A., Maggiolini M. (2012) Recent advances in the rationale design of GPER ligands. Curr Med Chem. 2012 Oct 31. [Epub ahead of print]
C Rosano, E Stec-Martyna, R Lappano, M Maggiolini (2011) Structure-based approach for the discovery of novel selective estrogen receptor modulators. Curr Med Chem 18: 8. 1188-1194
Marco Ponassi, Lamberto Felli, Stefania Parodi, Ugo Valbusa, Camillo Rosano (2011) Crystals of the hydrogenase maturation factor HypF N-terminal domain grown in microgravity, display improved internal order Journal of Crystal Growth 314: 1. 246-251 jan
Camillo Rosano (2011) Molecular model of hexokinase binding to the outer mitochondrial membrane porin (VDAC1): Implication for the design of new cancer therapies. Mitochondrion 11: 513-519
Francesca Bertola, Mirella Filocamo, Giorgio Casati, Matthew Mort, Camillo Rosano, Anna Tylki-Szymanska, Beyhan Tüysüz, Orazio Gabrielli, Serena Grossi, Maurizio Scarpa, Giancarlo Parenti, Daniela Antuzzi, Jaime Dalmau, Maja Di Rocco, Carlo Dionisi Vici, Ilyas Okur, Jordi Rosell, Attilio Rovelli, Francesca Furlan, Miriam Rigoldi, Andrea Biondi, David N Cooper, Rossella Parini (2011) IDUA mutational profiling of a cohort of 102 European patients with mucopolysaccharidosis type I: identification and characterization of 35 novel α-L-iduronidase (IDUA) alleles. Hum Mutat Mar
F Condorelli, E Stec-Martyna, J Zaborowska, L Felli, I Gemmi, M Ponassi, C Rosano (2011) Role of the Non-Receptor Tyrosine Kinase Fes in Cancer. Curr Med Chem
Camillo Rosano, Mattia Rocco (2010) Solution properties of full-length integrin alpha(IIb)beta3 refined models suggest environment-dependent induction of alternative bent /extended resting states. FEBS J 277: 15. 3190-3202
Rosamaria Lappano, Camillo Rosano, Paola De Marco, Ernestina Marianna De Francesco, Vincenzo Pezzi, Marcello Maggiolini (2010) Estriol acts as a GPR30 antagonist in estrogen receptor-negative breast cancer cells. Mol Cell Endocrinol 320: 1-2. 162-170
Emre Brookes, Borries Demeler, Camillo Rosano, Mattia Rocco (2010) The implementation of SOMO (SOlution MOdeller) in the UltraScan analytical ultracentrifugation data analysis suite: enhanced capabilities allow the reliable hydrodynamic modeling of virtually any kind of biomacromolecule. Eur Biophys J 39: 3. 423-435 Feb
2009
Maurizio Viale, Cinzia Cordazzo, Daniela de Totero, Roberta Budriesi, Camillo Rosano, Alberto Leoni, Pierfranco Ioan, Cinzia Aiello, Michela Croce, Aldo Andreani, Mirella Rambaldi, Patrizia Russo, Alberto Chiarini, Domenico Spinelli (2009) Inhibition of MDR1 activity and induction of apoptosis by analogues of nifedipine and diltiazem: an in vitro analysis. Invest New Drugs 29: 1. 98-109
Barbara Tappino, Nadia A Chuzhanova, Stefano Regis, Andrea Dardis, Fabio Corsolini, Marina Stroppiano, Emmanuel Tonoli, Tommaso Beccari, Camillo Rosano, Jan Mucha, Mariana Blanco, Marina Szlago, Maja Di Rocco, David N Cooper, Mirella Filocamo (2009) Molecular characterization of 22 novel UDP-N-acetylglucosamine-1-phosphate transferase alpha- and beta-subunit (GNPTAB) gene mutations causing mucolipidosis types IIalpha/beta and IIIalpha/beta in 46 patients. Hum Mutat 30: 11. E956-E973
Marina Lanciotti, Gianluca Caridi, Camillo Rosano, Simona Pigullo, Tiziana Lanza, Carlo Dufour (2009) Severe congenital neutropenia: a negative synergistic effect of multiple mutations of ELANE (ELA2) gene. Br J Haematol 146: 5. 578-580
Rosamaria Lappano, Camillo Rosano, Antonio Madeo, Lidia Albanito, Pierluigi Plastina, Bartolo Gabriele, Luca Forti, Lucia Anna Stivala, Domenico Iacopetta, Vincenza Dolce, Sebastiano Andò, Vincenzo Pezzi, Marcello Maggiolini (2009) Structure-activity relationships of resveratrol and derivatives in breast cancer cells. Mol Nutr Food Res 53: 7. 845-858
Emanuele Persichetti, Nadia A Chuzhanova, Andrea Dardis, Barbara Tappino, Sandra Pohl, Nick S T Thomas, Camillo Rosano, Chiara Balducci, Silvia Paciotti, Silvia Dominissini, Anna Lisa Montalvo, Michela Sibilio, Rossella Parini, Miriam Rigoldi, Maja Di Rocco, Giancarlo Parenti, Aldo Orlacchio, Bruno Bembi, David N Cooper, Mirella Filocamo, Tommaso Beccari (2009) Identification and molecular characterization of six novel mutations in the UDP-N-acetylglucosamine-1-phosphotransferase gamma subunit (GNPTG) gene in patients with mucolipidosis III gamma. Hum Mutat 30: 6. 978-984
Alessandra Zanetti, Elena Ferraresi, Luigi Picci, Mirella Filocamo, Rossella Parini, Camillo Rosano, Rosella Tomanin, Maurizio Scarpa (2009) Segregation analysis in a family at risk for the Maroteaux-Lamy syndrome conclusively reveals c.1151G>A (p.S384N) as to be a polymorphism. Eur J Hum Genet 17: 9. 1160-1164
Tatiana Fancello, Andrea Dardis, Camillo Rosano, Patrizia Tarugi, Barbara Tappino, Stefania Zampieri, Elisa Pinotti, Fabio Corsolini, Simona Fecarotta, Adele D'Amico, Maja Di Rocco, Graziella Uziel, Sebastiano Calandra, Bruno Bembi, Mirella Filocamo (2009) Molecular analysis of NPC1 and NPC2 gene in 34 Niemann-Pick C Italian patients: identification and structural modeling of novel mutations. Neurogenetics 10: 3. 229-239
Sara Cesarini, Andrea Spallarossa, Angelo Ranise, Silvia Schenone, Camillo Rosano, Paolo La Colla, Giuseppina Sanna, Bernardetta Busonera, Roberta Loddo (2009) N-acylated and N,N'-diacylated imidazolidine-2-thione derivatives and N,N'-diacylated tetrahydropyrimidine-2(1H)-thione analogues: synthesis and antiproliferative activity. Eur J Med Chem 44: 3. 1106-1118 Mar
2008
Serena Grossi, Stefano Regis, Camillo Rosano, Fabio Corsolini, Graziella Uziel, Maria Sessa, Maja Di Rocco, Giancarlo Parenti, Federica Deodato, Vincenzo Leuzzi, Roberta Biancheri, Mirella Filocamo (2008) Molecular analysis of ARSA and PSAP genes in twenty-one Italian patients with metachromatic leukodystrophy: identification and functional characterization of 11 novel ARSA alleles. Hum Mutat 29: 11. E220-E230
Marco A Pierotti, Claudio Lombardo, Camillo Rosano (2008) Nanotechnology: going small for a giant leap in cancer diagnostics and therapeutics. Tumori 94: 2. 191-196
Mattia Rocco, Camillo Rosano, John W Weisel, David A Horita, Roy R Hantgan (2008) Integrin conformational regulation: uncoupling extension/tail separation from changes in the head region by a multiresolution approach. Structure 16: 6. 954-96
M G Pittis, M Donnarumma, A L E Montalvo, S Dominissini, M Kroos, C Rosano, M Stroppiano, M G Bianco, M A Donati, G Parenti, A D'Amico, G Ciana, M Di Rocco, A Reuser, B Bembi, M Filocamo (2008) Molecular and functional characterization of eight novel GAA mutations in Italian infants with Pompe disease. Hum Mutat 29: 6. E27-E36 Jun 2007
Michela Donnarumma, Stefano Regis, Barbara Tappino, Camillo Rosano, Stefania Assereto, Fabio Corsolini, Maja Di Rocco, Mirella Filocamo (2007) Molecular analysis and characterization of nine novel CTSK mutations in twelve patients affected by pycnodysostosis. Mutation in brief #961. Online. Hum Mutat 28: 5.
Ilaria Gnemmi, Claudia Scotti, Donata Cappelletti, Pier Luigi Canonico, Fabrizio Condorelli, Camillo Rosano (2007) Expression, purification and preliminary crystallographic studies on the catalytic region of the nonreceptor tyrosine kinase Fes. Acta Crystallogr Sect F Struct Biol Cryst Commun 63: Pt 1. 18-20 Jan 2006
Camillo Rosano, Simone Zuccotti, Laura Sturla, Floriana Fruscione, Michela Tonetti, Martino Bolognesi (2006) Quaternary assembly and crystal structure of GDP-D-mannose 4,6 dehydratase from Paramecium bursaria Chlorella virus. Biochem Biophys Res Commun 339: 1. 191-195
Alessandra Corazza, Camillo Rosano, Katiuscia Pagano, Vera Alverdi, Gennaro Esposito, Cristina Capanni, Francesco Bemporad, Georgia Plakoutsi, Massimo Stefani, Fabrizio Chiti, Simone Zuccotti, Martino Bolognesi, Paolo Viglino (2006) Structure, conformational stability, and enzymatic properties of acylphosphatase from the hyperthermophile Sulfolobus solfataricus. Proteins 62: 1. 64-79
M P Bicocchi, M Pasino, C Rosano, A C Molinari, E Della Valle, T Lanza, F Bottini, M Acquila (2006) Insight into molecular changes of the FIX protein in a series of Italian patients with haemophilia B. Haemophilia 12: 3. 263-270
Maura Acquila, Mirella Pasino, Tiziana Lanza, Angelo Claudio Molinari, Camillo Rosano, Maria Patrizia Bicocchi (2005) Exon skipping partially restores factor VIII coagulant activity in patients with mild hemophilia A with exon 13 duplication. Haematologica 90: 7. 997-999
Maria Patrizia Bicocchi, Mirella Pasino, Tiziana Lanza, Federico Bottini, Angelo Claudio Molinari, Camillo Rosano, Maura Acquila (2005) Ectopic mRNA analysis and molecular modelling substantiate severe haemophilia in a patient with a FVIII gene splice mutation. Thromb Haemost 93: 2. 391-392
Maria Patrizia Bicocchi, Mirella Pasino, Tiziana Lanza, Federico Bottini, Angelo Claudio Molinari, Daniela Caprino, Camillo Rosano, Maura Acquila (2005) Small FVIII gene rearrangements in 18 hemophilia A patients: five novel mutations. Am J Hematol 78: 2. 117-122
Simone Zuccotti, Camillo Rosano, Francesco Bemporad, Massimo Stefani, Martino Bolognesi (2005) Preliminary characterization of two different crystal forms of acylphosphatase from the hyperthermophile archaeon Sulfolobus solfataricus. Acta Crystallogr Sect F Struct Biol Cryst Commun 61: Pt 1. 144-146
Camillo Rosano, Simone Zuccotti, Martino Bolognesi (2005) The three-dimensional structure of beta2 microglobulin: results from X-ray crystallography. Biochim Biophys Acta 1753: 1. 85-91 Nov 2004
Camillo Rosano, Simone Zuccotti, Beatrice Cobucci-Ponzano, Marialuisa Mazzone, Mosè Rossi, Marco Moracci, Maxim V Petoukhov, Dmitri I Svergun, Martino Bolognesi (2004) Structural characterization of the nonameric assembly of an Archaeal alpha-L-fucosidase by synchrotron small angle X-ray scattering. Biochem Biophys Res Commun 320: 1. 176-182
Simone Zuccotti, Camillo Rosano, Matteo Ramazzotti, Donatella Degl'Innocenti, Massimo Stefani, Giampaolo Manao, Martino Bolognesi (2004) Three-dimensional structural characterization of a novel Drosophila melanogaster acylphosphatase. Acta Crystallogr D Biol Crystallogr 60: Pt 6. 1177-1179
Annalisa Relini, Silvia Torrassa, Ranieri Rolandi, Alessandra Gliozzi, Camillo Rosano, Claudio Canale, Martino Bolognesi, Georgia Plakoutsi, Monica Bucciantini, Fabrizio Chiti, Massimo Stefani (2004) Monitoring the process of HypF fibrillization and liposome permeabilization by protofibrils. J Mol Biol 338: 5. 943-957
C Rosano, S Zuccotti, P Mangione, S Giorgetti, V Bellotti, F Pettirossi, A Corazza, P Viglino, G Esposito, M Bolognesi (2004) beta2-microglobulin H31Y variant 3D structure highlights the protein natural propensity towards intermolecular aggregation. J Mol Biol 335: 4. 1051-1064 Jan 2003
Maria P Bicocchi, Mirella Pasino, Tiziana Lanza, Federico Bottini, Elio Boeri, Pier G Mori, Angelo C Molinari, Camillo Rosano, Maura Acquila (2003) Analysis of 18 novel mutations in the factor VIII gene. Br J Haematol 122: 5. 810-817
Simone Zuccotti, Camillo Rosano, Palma Mangione, Vittorio Bellotti, Martino Bolognesi (2003) Preliminary crystallographic characterization of the human beta2 microglobulin His31Tyr mutant in a tetrameric assembly. Acta Crystallogr D Biol Crystallogr 59: Pt 7. 1270-1272 Jul 2002
Camillo Rosano, Simone Zuccotti, Monica Bucciantini, Massimo Stefani, Giampietro Ramponi, Martino Bolognesi (2002) Crystal structure and anion binding in the prokaryotic hydrogenase maturation factor HypF acylphosphatase-like domain. J Mol Biol 321: 5. 785-796
Camillo Rosano, Simone Zuccotti, Massimo Stefani, Monica Bucciantini, Giampietro Ramponi, Martino Bolognesi (2002) Crystallization and preliminary X-ray characterization of the acylphosphatase-like domain from the Escherichia coli hydrogenase maturation factor HypF. Acta Crystallogr D Biol Crystallogr 58: Pt 3. 524-525 Mar 2001
S Zuccotti, D Zanardi, C Rosano, L Sturla, M Tonetti, M Bolognesi (2001) Kinetic and crystallographic analyses support a sequential-ordered bi bi catalytic mechanism for Escherichia coli glucose-1-phosphate thymidylyltransferase. J Mol Biol 313: 4. 831-843
M E Stroppolo, A Pesce, M D'Orazio, P O'Neill, D Bordo, C Rosano, M Milani, A Battistoni, M Bolognesi, A Desideri (2001) Single mutations at the subunit interface modulate copper reactivity in Photobacterium leiognathi Cu,Zn superoxide dismutase. J Mol Biol 308: 3. 555-563 May 2000
C Rosano, A Bisso, G Izzo, M Tonetti, L Sturla, A De Flora, M Bolognesi (2000) Probing the catalytic mechanism of GDP-4-keto-6-deoxy-d-mannose Epimerase/Reductase by kinetic and crystallographic characterization of site-specific mutants. J Mol Biol 303: 1. 77-91
M Tonetti, C Rosano, A Bisso, G Izzo, S Zuccotti, A De Flora, M Bolognesi (2000) Site-directed mutagenesis and crystallographic studies of GDP-4-keto-6-deoxy-D-mannose epimerase/reductase (GMER) from E-coli Italian Journal of Biochemistry 49: 1. 12
S Bruno, S Bettati, M Manfredini, A Mozzarelli, M Bolognesi, D Deriu, C Rosano, A Tsuneshige, T Yonetani, E R Henry (2000) Oxygen binding by alpha(Fe2+)2beta(Ni2+)2 hemoglobin crystals. Protein Sci 9: 4. 683-692 Apr
C Rosano, G Izzo, L Sturla, A Bisso, M Tonetti, M Bolognesi (2000) The high resolution structure of GDP 4-keto-6-deoxy-D-mannose epimerase/reductase. Croatica Chemica Acta 73: 3. 887 Sep
1999
C Rosano, E Sabini, M Rizzi, D Deriu, G Murshudov, M Bianchi, G Serafini, M Magnani, M Bolognesi (1999) Binding of non-catalytic ATP to human hexokinase I highlights the structural components for enzyme-membrane association control. Structure 7: 11. 1427-1437
M Bolognesi, C Rosano, R Losso, A Borassi, M Rizzi, J B Wittenberg, A Boffi, P Ascenzi (1999) Cyanide binding to Lucina pectinata hemoglobin I and to sperm whale myoglobin: an x-ray crystallographic study. Biophys J 77: 2. 1093-1099
D Bordo, D Matak, K Djinovic-Carugo, C Rosano, A Pesce, M Bolognesi, M E Stroppolo, M Falconi, A Battistoni, A Desideri (1999) Evolutionary constraints for dimer formation in prokaryotic Cu,Zn superoxide dismutase. J Mol Biol 285: 1. 283-296
C Rosano, P Arosio, M Bolognesi (1999) The X-ray three-dimensional structure of avidin. Biomol Eng 16: 1-4. 5-12 Dec 1998
M E Stroppolo, S Nuzzo, A Pesce, C Rosano, A Battistoni, M Bolognesi, S Mobilio, A Desideri (1998) On the coordination and oxidation states of the active-site copper ion in prokaryotic Cu,Zn superoxide dismutases. Biochem Biophys Res Commun 249: 3. 579-582
E Nardone, C Rosano, P Santambrogio, F Curnis, A Corti, F Magni, A G Siccardi, G Paganelli, R Losso, B Apreda, M Bolognesi, A Sidoli, P Arosio (1998) Biochemical characterization and crystal structure of a recombinant hen avidin and its acidic mutant expressed in Escherichia coli. Eur J Biochem 256: 2. 453-460
E Sabini, C Rosano, C Capasso, M Rizzi, M Bolognesi, M Bianchi, G Serafini, E Bartolucci, M Magnani (1998) Expression, purification and preliminary studies of human hexokinase type I. Protein and Peptide Letters 5: 4. 237 