Jeffrey Keelan

Women's and Infants' Health
University of Western Australia

Interests

Inflammation in pregnancy; nanoparticle drug delivery in pregnancy; microbiome in pregnancy and its relationship to pregnancy disorders; placental drug disposition; placental differentiation; placental endocrinology and immunology.

Projects

Delivery of drugs to the placenta using targeted nanoparticles; use of anti-inflammatory drugs and antibiotics to prevent preterm birth; wnt antagonists and their role in placentation; the vaginal and amniotic microbiome in normal and abnormal pregnancies

Publications

Nanotechnology related publications: H Yang, C Sun, Z Fan, X Tian, L Yan, L Du, Y Liu, C Chen, X Liang, GJ Anderson, JA Keelan, Y Zhao, G Nie. (2012) Effects of gestational age and surface modification on materno-fetal transfer of nanoparticles in murine pregnancy. Scientific Reports, 2:847; EPub Nov 13 2012. JA Keelan (2012) Exploiting nanodrug delivery in pregnancy. Medical Forum WA, Sept 2012 JA Keelan (2011) Nanotoxicology: Nanoparticles versus the placenta. Nature Nanotechnology 6(5): 263-4. Invited editorial. V Menezes, A Malek, JA Keelan. (2011) Nanoparticulate drug delivery in pregnancy: placental passage and fetal exposure. Current Pharmaceutical Biotechnology: Drugs in Pregnancy (Special edition). 12 (5), 731-742. [Epub ahead of print] (invited review; cover illustration).