Publications
PAPERS ONLY FROM 2000 ONWARDS
1. Piret, Vankoningsloo, Noël, Mejia Mendoza, Delhalle, Lucas, Saout & Toussaint. Inflammation response at the transcriptional level of HepG2 cells induced by multi-walled carbon nanotubes. J Physics: Conference Series, in press.
2. Lozano, Mejia, Masereel, Toussaint, Lison, Delhalle & Lucas. Development of a PIXE analysis method for the determination of the biopersistence of SiC and TiC nanoparticles in rat lungs. Nanotoxicology, Early online, 1-7. Apr 20. [Epub ahead of print], 2011.
3. Laloy, Robert, Marbehant, Mullier, Mejia, Piret, Delhalle, Lucas, Chatelain, Dogné, Toussaint, Masereel & Rolin. Validation of the calibrated thrombin generation test (cTGT) as the gold standard assay to assess the procoagulant activity of nanomaterials. Nanotoxicology, Early online, 1-20. April 13. [Epub ahead of print], 2011.
4. Vankoningsloo, Piret, Saout, Noël, Mejia, Coquette, Zouboulis, Lucas & Toussaint. Pro-inflammatory effects of different MWCNT dispersions in p16INK4A-deficient telomerase-expressing human keratinocytes but not in human SV-40 immortalized sebocytes. Nanotoxicology, Early online, 1-17. Feb 28. [Epub ahead of print], 2011.
5. Mejia, Toussaint, Masereel & Lucas. Fate of SiC nanoparticle dispersions in gastric fluid. In: Proceedings of the 2nd International Conference on Nanotechnology: Fundamentals and Applications. Ottawa, Ontario, Canada, 28-29 July 2011. Paper No. XXX (Number assigned by the OpenConf System), in press.
6. Vo, de Saint-Hubert, Morrhaye, Godard, Geenen, Martens, Debacq-Chainiaux, Swine & Toussaint. Transcriptomic biomarkers of the response of hospitalized geriatric patients admitted with heart failure. Comparison with hospitalized geriatric patients with infectious diseases or hip fracture. Mech Ageing Dev 132, 131-139, 2011
7. Vo, Godard, de Saint-Hubert, Morrhaye, Debacq-Chainiaux, Swine, Geenen, Martens & Toussaint. Differentially abundant transcripts in PBMC of hospitalized geriatric patients with hip fracture compared to healthy aged controls. Exp Gerontol 46, 257-264, 2011
8. de Saint-Hubert, Jamart, Morrhaye, Martens, Geenen, Vo, Toussaint & Swine. Serum IL-6 and IGF-1 improve the clinical prediction of functional decline in hospitalized older patients. Aging Clin Exp Res, DOI: 10.3275/7028, 2010 May 6. [Epub ahead of print]
9. Toussaint, Weemaels, Debacq-Chainiaux, Scharffetter-Kochanek & Wlaschek. Artefactual effects of oxygen on cell culture models of cellular senescence and stem cell biology. J Cell Physiol, 226, 315-321, 2011
10. Mejia, Tichelaar, Saout, Toussaint, Masereel, Mekhalif, Lucas & Delhalle. Effects of the dispersion methods in Pluronic F108 on the size and the surface composition of MWCNT and their implications in toxicology assessment. J Nanoparticle Res, 13, 655-667, 2011 DOI: 10.1007/s11051-010-0063-7
11. Rose, Romeo, Dato, Crocco, Bruni, Hervonen, Majamaa, Sevini, Franceschi, Passarino & the GEHA Project Consortium (Bezrukov, Blanché, Bolund, Christensen, Deiana, Gonos, Kirkwood, Kristensen, Leon, Pelicci, Perola, Poulain, Rea, Remacle, Robine, Schreiber, Sikora, Slagboom, Spazzafumo, Stazi, Toussaint, Vaupel). Somatic point mutations in mtDNA control region are influenced by genetic background and associated with healthy aging. PloS One, 5(10):e13395, 2010.
12. Sergent, Piront, Meurice, Toussaint & Schneider. Anti-inflammatory effects of dietary phenolic compounds in an in vitro model of inflamed human intestinal epithelium. Chem Biol Interact, 188, 659-67, 2010
13. Vahooren, Dewaele, Libert, Engelborghs, De Deyn, Toussaint, Debacq-Chainiaux, Poulain, Glupczynski, Franceschi, Jaspers, van Der Pluijm, Hoeijmakers & Chen. Serum N-Glycan Profile Shift During Human Ageing. Exp Gerontol, 45, 738-743, 2010
14. Van De Walle, During, Piront, Toussaint, Schneider & Larondelle. Physico-pathological parameters affect the activation of inflammatory pathways by deoxynivalenol in Caco-2 cells. Toxicol in Vitro, 24, 1890-1898, 2010
15. Vo, Godard, de Saint-Hubert, Morrhaye, Swine, Geenen, Martens, Debacq-Chainiaux & Toussaint. Transcriptomic biomarkers of the response of hospitalized geriatric patients to infectious diseases. Immunity Ageing, 7, 9, pp10, 2010
16. Vankoningsloo, Piret, Saout, Noel, Mejia, Zouboulis, Delhalle, Lucas & Toussaint. Cytotoxicity of multi-walled carbon nanotubes in three skin cellular models: effects of sonication, dispersive agents and corneous layer of reconstructed epidermis. Nanotoxicology, 4, 84-97, 2010
17. Piret, Detriche, Vigneron, Vankoningsloo, Rolin, Mejia Mendoza, Masereel, Lucas, Delhalle, Luizi, Saout & Toussaint. Dispersion of multi-walled carbon nanotubes in biocompatible dispersants. J Nanoparticle Res, 12, 75-82, 2010 ; DOI: 10.1007/s11051-009-9697-8
18. Van De Walle, Sergent, Piront, Toussaint, Schneider & Larondelle. Deoxynivalenol affects in vitro intestinal epithelial cell barrier integrity through inhibition of protein synthesis. Toxicol Applied Pharmacol, 245, 291-298, 2010
19. Robbens, Vanparys, Nobels, Blust, Van Hoecke, Janssen, De Schamphelaere, Roland, Blanchard, Silvestre, Gillardin, Kestemont, Anthonissen, Toussaint, Saout, Vankoningsloo, Alfaro-Moreno, Hoet, Gonzalez, Dubruel, Troisfontaines. Eco-, geno- and human toxicology of bio-active nanoparticles for biomedical applications. Toxicology, 269,170-181, 2010
20. Debacq-Chainiaux, Boilan, Dedessus Le Moutier, Weemaels & Toussaint. p38MAPK in the senescence of human and murine fibroblasts. Adv Exp Med Biol, 694, 126-137, 2010
21. Bertrand-Vallery, Belot, Dieu, Delaive, Ninane, Demazy, Raes, Salmon, Poumay, Debacq-Chainiaux & Toussaint. Proteomic profiling of human keratinocytes undergoing UVB-induced alternative differentiation reveals TRIpartite Motif Protein 29 as a survival factor. PLoS ONE, 5(5), e10462, 2010.
22. Vo, Godard, de Saint-Hubert, Morrhaye, Bauwens, Debacq-Chainiaux, Glupczynski, Swine, Geenen, Martens & Toussaint. Transcriptomic biomarkers of human ageing in peripheral blood mononuclear cell total RNA. Exp Gerontol, 45, 188-194, 2010
23. Bertrand-Vallery, Boilan, Ninane, Demazy, Friguet, Toussaint, Poumay & Debacq-Chainiaux. Repeated exposures to UVB induce differentiation rather than senescence of human keratinocytes lacking p16INK-4A. Biogerontology, 11, 167-182, 2010. DOI: 10.1007/s10522-009-9238-y.
24. Debacq-Chainiaux, Erusalimsky, Campisi & Toussaint. Methods to detect senescence-associated beta-galactosidase (SA-ß gal) activity, a biomarker of senescent cells in culture and in vivo. Nature Protocols, 4, 1798-1806, 2009
25. Zdanov, Toussaint & Debacq-Chainiaux. p53 and ATF-2 partly mediate the overexpression of COX-2 in H2O2-induced premature senescence of human fibroblasts. Biogerontology, 10, 291-298, 2009
26. Saout & Toussaint. The developent of nanotoxicity assays for regulatory purposes. Science & Technology, 4, 124-125, 2009
27. Scheckhuber, Grief, Boilan, Luce, Debacq-Chainiaux, Rittmeyer, Gredilla, Kolbesen, Toussaint & Osiewacz. Age-related cellular copper dynamics in the fungal ageing model Podospora anserina and in ageing human fibroblasts. PLoS ONE 4(3): e4919. doi:10.1371/journal.pone.0004919, 14 pp, 2009
28. Debacq-Chainiaux, Pascal, Boilan, Bastin, Bauwens & Toussaint. Screening of senescence associated genes with specific DNA array reveals the role of IGFBP-3 in premature senescence of human diploid fibroblasts. Free Radicals Biol Med, 44 1817-1832, + Suppl. Mat., 2008
29. Chrétien, Dierick, Delaive, Larsen, Dieu, Raes, Deroanne, Roepstorff & Toussaint. Role of TGF-ß1-independent changes in protein neosynthesis, p38alphaMAPK and cdc42 in hydrogen peroxide-induced senescence-like morphogenesis. Free Radicals Biol Med, 44 1732-1751, + Suppl. Mat., 2008
30. Chrétien, Piront, Delaive, Demazy, Ninane & Toussaint. Increased abundance of cytoplasmic and nuclear caveolin 1 in human diploid fibroblasts in H2O2-induced premature senescence and interplay with p38 alpha MAPK. FEBS Lett, 582 1685-1692, 2008
31. Borlon, Weemaels, Godard, Debacq-Chainiaux, Lemaire, Deroanne, Toussaint, O. Expression profiling of senescence-associated genes in human dermis from young and old donors. Biogerontology 9,197-208, 2008
32. Glotin, Debacq-Chainiaux, Brossas, Faussat, Tréton, Zubielewicz, Toussaint & Mascarelli. Prematurely senescent ARPE-19 cells display features of age-related macular degeneration: functional genomic evidence. Free Radicals Biol Med , 44 1348-1361, + Suppl. Mat., 2008
33. Bigot, Jacquemin, Debacq-Chainiaux, Butler-Browne, Toussaint, Furling & Mouly. Replicative aging down regulates the myogenic regulatory factors in human myoblasts. Biol Cell 100, 189-99, 2008
34. Borlon, Vankoningsloo, Godard, Debacq-Chainiaux & Toussaint. Identification of p53-dependent genes potentially involved in UVB-mediated premature senescence of human skin fibroblasts using siRNA technology. Mech Ageing Dev, 129, 109-119, 2008.
35. Chrétien, Delaive, Dieu, Demazy, Ninanne, Raes & Toussaint. Upregulation of annexin 2 in H2O2-induced premature senescence as evidenced by 2D-DIGE proteome analysis. Exp Gerontol, 43, 353-359 + Suppl. Mat., 2008
36. Ovesna, Slaby, Toussaint, Kodicek, Marsik, Pouchova & Vanek. High throughput ‘omics’ approaches to assess the effects of phytochemicals in human health studies. Br J Nutr, 99, ES130-ES137, 2008
37. Mortensen A, Sorensen IK, Wilde C, Dragoni S, Mullerová D, Toussaint O, Zloch Z, Sgaragli G, Ovesná J. Biological models for phytochemical research: from cell to human organism. Br J Nutr, 99, ES118-126, 2008
38. Borlon, Godard, Eskes, Hartung, Zuang & Toussaint. The usefulness of toxicogenomics for predicting acute skin irritation on in vitro reconstructed human epidermis. Toxicology, 242, 157-66, 2007.
39. Zdanov, Bernard, Debacq-Chainiaux, Martien, Gosselin, Vercamer, Chelli, Toussaint & Abbadie. Normal or stress-induced fibroblast senescence involves COX-2 activity. Exp Cell Res 313 :3046-56, 2007
40. Borlon, Debacq-Chainiaux, Hinrichs, Scharffetter-Kochanek, Toussaint, Wlaschek. Expression profile of psoralen plus UVA-induced premature senescence in skin fibroblasts resembles a combined DNA-damage and stress-induced cellular senescence response phenotype. Exp Gerontol 42, 911-923, 2007
41. Pascal, Debacq-Chainiaux, Boilan, Ninane, Raes & Toussaint. Heme oxygenase-1 and interleukin-11 are overexpressed in stress-induced premature senescence of human WI-38 fibroblasts induced by tert-butylhydroperoxide and ethanol. Biogerontology, 8, 409-22, 2007
42. Zdanov, Debacq-Chainiaux, Remacle & Toussaint. Identification of p38MAPK-dependent Genes Involved in H2O2-induced Premature Senescence of IMR-90 hTERT Human Fibroblasts. FEBS Lett, 580, 6455-6463, 2006.
43. Debacq-Chainiaux, Borlon, De Hertogh, Remacle, Morvan, Vallée & Toussaint. Identification of potential anti-photoageing algal compounds using an in vitro model of photoageing J Pharm Pharmacol, 58, 1577-1583, 2006
44. Toussaint, Rayet, Chainiaux, Zouboulis, Butler-Browne, Chen & Kirkwood. LINK-AGE: Coordination and consolidation of European biogerontology: en route towards formation of a European college of biogerontology. Mech Ageing Dev, 27, 761-762, 2006
45. Pascal, Debacq-Chainiaux, Chrétien, Bastin, Dabée, Bertholet, Remacle & Toussaint. Comparison of replicative senescence and stress-induced premature senescence combining differential display and low-density DNA arrays. FEBS Lett, 579, 3651-3659, 2005
46. Debacq-Chainiaux, Borlon, Pascal, Royer, Ninane, Carrard, de Longueville, Boffe, Eliaers, Friguet, Remacle & Toussaint. Repeated exposures of human skin fibroblasts to UVB at subcytotoxic level trigger premature senescence through the TGF-ß1 signaling pathway. J Cell Sci, 118, 743-758, 2005.
47. de Magalhães, Costa & Toussaint. HAGR : The Human Ageing Genomic Resources. Nucl Acid Res, 33, D537-D543, 2005
48. Matthews, Haimes, Duguet, Clark, Swine & Toussaint. Informed consent of very old patients and modern genomics. Biogerontology, 6, 81-84, 2005
49. de Magalhães & Toussaint. GenAge: a genomic and proteomic network map of human ageing. FEBS Lett, 571, 243-247, 2004.
50. de Magalhaes, Chainiaux, de Longueville, Mainfroid, Migeot, Marcq, Remacle, Salmon & Toussaint. Gene expression and regulation in H2O2-induced premature senescence of human foreskin fibroblasts expressing or not telomerase. Exp Gerontol,39, 1379-1389, 2004
51. Salmon, Dedessus Le Moutier, Wenders, Chiarizia, Eliaers, Remacle, Royer, Pascal & Toussaint. Role of the PLA2-independent peroxiredoxin VI activity in the survival of immortalized fibroblasts exposed to cytotoxic oxidative stress. FEBS Lett, 557, 25-32, 2004
52. de Magalhaes & Toussaint. How bioinformatics can help reverse engineer human aging. Ageing Res. Rev., 3, 125-141, 2004.
53. Toussaint, Remacle, Dumont, Dierick, Pascal, Frippiat, Magalhaes & Chainiaux. Oxidative stress-induced senescence of human diploid cells. Nature Encyclopedia of Life Science (Macmillan, Nature Publishing group). http://www.els.net article 3441, version 2., 2004
54. de Magalhaes & Toussaint. Telomeres and telomerase, a modern Fountain of Youth? Rejuvenation Research, 7, 126-133, 2004
55. Carrard, Dieu, Raes, Toussaint & Friguet. Impact of aging on proteasome structure and function in human lymphocytes. Int. J. Biochem. Cell Biol. 35, 728-739, 2003
56. Toussaint. View of a young biogerontologist on the in vitro biogerontological model systems. Editorial. Exp. Gerontol, 38, 1229-1230, 2003
57. Dierick, Wenders, Chainiaux, Remacle, Fisher & Toussaint. Retrovirally-mediated overexpression of peroxiredoxin VI protects WI-38 human diploid fibroblasts against tert-butylhydroperoxide and UVB cytotoxicity. Biogerontology, 4, 125-131, 2003.
58. Frippiat, Remacle & Toussaint. Down-regulation and decreased activity of cyclin-dependent kinase 2 in H2O2-induced premature senescence. Int. J. Biochem. Cell Biol., 35, 246-254, 2003
59. Frippiat, Remacle & Toussaint. Signal transduction in H2O2-induced senescence-like phenotype in human diploid fibroblasts. Free Rad. Biol. Med., 33, 1334-1346, 2002
60. Dierick, Kalume, Wenders, Salmon, Dieu, Raes, Roepstorff & Toussaint. Identification of 30 protein species involved in replicative senescence and stress-induced premature senescence. FEBS Lett, 531, 499-504, 2002.
61. Dierick, Eliaers, Remacle, Raes, Fey, Mose Larsen & Toussaint. Stress-induced premature senescence and replicative senescence are different phenotypes. Proteomic evidence. Biochem. Pharmacol. 64, 1011-1017, 2002
62. Toussaint, Royer, Salmon & Remacle. Stress-induced premature senescence and tissue ageing. Biochem. Pharmacol. 64, 1007-1009, 2002.
63. Toussaint, Dumont, Dierick, Pascal, Frippiat, Zdanov, Magalhaes, Royer & Chainiaux. Hayflick mosaic or stress-induced premature senescence ? Is it stress-induced premature senescence or replicative senescence that occurs in vivo ? Int. J. Biochem. Cell Biol. 34, 1415-1429, 2002
64. Chainiaux, Magalhaes, Eliaers, Remacle & Toussaint. UV-B induced premature senescence of human diploid skin fibroblasts. Int. J. Biochem. Cell Biol. 34, 1331-1339, 2002
65. Magalhaes, Chainiaux, Remacle & Toussaint. Stress-induced premature senescence in BJ and hTERT-BJI human diploid fibroblasts. FEBS Lett. 523 157-162, 2002
66. Dumont, Chainiaux, Eliaers, Petropoulou, Remacle, Koch-Brandt, Gonos & Toussaint. Overexpression of apolipoprotein J in human fibroblasts protects against cytotoxicity and premature senescence induced by ethanol and tert-butylhydroperoxyde. Cell Stress & Chaperones 7 , 23-35, 2002.
67. Dierick, Dieu, Remacle, Raes, Roepstorff & Toussaint. Proteomics in experimental gerontology. Exp. Gerontol. 37, 721-734, 2002
68. Magalhães & Toussaint. The Evolution of Mammalian Aging. Exp. Gerontol. 37, 769-775, 2002.
69. Toussaint, Remacle, Dierick, Pascal, Frippiat, Royer & Chainiaux. Approach of evolutionary theories of ageing, stress, senescence-like phenotypes, calorie restriction and hormesis from the view point of far-from-equilibrium thermodynamics. Mech. Ageing Dev. 123, 937-946, 2002
70. Toussaint, Salmon, Dierick, de Magalhaes, Pascal, Zdanov, Wenders, Borlon, Chrétien, Chiarizia, Remacle, de Longueville, Zammatteo & Chainiaux. TOXICO-SIPS. Development of a valuable tool of in vitro toxicology, toxicoproteomics and toxicotranscriptomics based on stress-induced premature senescence (SIPS). Applied Genomics Proteomics 1, 227-324, 2002
71. Toussaint, Dumont, Remacle, Dierick, Pascal, Frippiat, Magalhaes, Zdanov & Chainiaux. Stress-induced premature senescence or stress-induced senescence-like phenotype : one in vivo reality, two possible definitions ? How stress, cellular behaviors, growth kinetics and cell heterogeneity interact in senescence. Scientific World J.. 2, January, 230-247, 2002 http://www.thescientificworld.com
72. Toussaint, Remacle, Dumont, Dierick, Pascal, Frippiat, Royer & Chainiaux. Stress-induced premature senescence : from biomarkers to likeliness of in vivo occurence. Biogerontology. 3, 13-17, 2002
73. Frippiat, Chen, Zdanov, Magalhaes, Remacle & Toussaint. Subcytotoxic H2O2 stress triggers a release of Transforming Growth Factor-ß1, which induces stress-induced premature senescence of human diploid fibroblasts. J. Biol. Chem. 276, 2531-2537, 2001.
74. Dumont, Royer, Pascal, Dierick, Chainiaux, Frippiat, Eliaers, Remacle & Toussaint. Growth kinetics rather than stress cause accelerated telomere shortening in cultures of human diploid fibroblasts in oxidative stress-induced premature senescence. FEBS Lett. 502, 109-112, 2001.
75. Petropoulou, Trougakos, Kolettas, Toussaint & Gonos. Clusterin/apolipoprotein J is a novel biomarker of senescence that does not affect the proliferative capacity of human diploid fibroblasts. FEBS Lett. 509, 287-297, 2001.
76. Toussaint, Remacle, Dierick, Pascal, Frippiat, Magalhaes & Chainaux. Hormesis : a quest for virtuality ? Human Exp. Toxicol., 20, 311-314, 2001.
77. Brack, Lithgow, Osiewacz & Toussaint. Molecular and Cellular Gerontology. EMBO J. 19 1929-1934, 2000.
78. Toussaint, Remacle, Clark, Gonos, Franceschi & Kirkwood. Molecular, Cellular and Tissue Gerontology. BioEssays 22:954-956, 2000.
79. Chen, Tu, Catania, Burton, Toussaint & Dilley. Involvement of Rb family proteins, focal adhesion proteins and protein synthesis in senescent morphogenesis induced by hydrogen peroxide. J. Cell Sci., 113 (Pt 22), 4087-4097, 2000.
80. Dumont, Chen, Burton, Gonos, Frippiat, Mazarati, Eliaers, Remacle & Toussaint. Induction of replicative senescence biomarkers by sublethal oxidative stresses in normal human fibroblast. Free Rad. Biol. Med., 28, 361-373, 2000.
81. Frippiat, Chen, Remacle & Toussaint. Cell cycle regulation in H2O2-induced premature senescence of human diploid fibroblasts. Regulatory control exerted by the human papilloma virus E6 and E7 proteins. Exp. Gerontol., 35 (6-7) 733-746, 2000.
82. Toussaint, Medrano & Zglinicki. Stress-induced premature senescence of human diploid fibroblasts and melanocytes. Exp. Gerontol., 35 (8) 927-945, 2000.
83. Toussaint, Baret, Brion, Cras, Collette, De Deyn, Geenen, Kienlen-Campard, Labeur, Legros, Nève, Octave, Piérard, Salmon, van den Bosch de Aguilar, Van der Linden, Van Leuven & Vanfleteren. Experimental gerontology in Belgium: from model systems to age-related diseases. Invited review. Exp. Gerontol., 35 (8) 901-916, 2000.
84. Toussaint. Editorial. Biological ageing : Euroconference on Molecular, Cellular and Tissue Gerontology. Exp. Gerontol., 35 (6-7) 669-670, 2000.
85. Dumont, Balbeur, Remacle & Toussaint. Appearance of biomarkers of in vitro ageing after successive stimulations of WI-38 fibroblasts with IL-1α and TNFα : senescence associated ß-galactosidase activity and morphotype transition. J. Anat., 197, 529-537, 2000.
86. Frippiat, Dierick, Remacle & Toussaint. Consideration of heteroduplexes and homoduplexes for the quantification by competitive PCR of deletions of human mitochondrial DNA with ageing of tissues and cells. Biogerontology, 1 (3), 279-283, 2000.
87. Toussaint, Dumont, Dierick, Pascal, Frippiat, Chainiaux, Magalhaes, Eliaers & Remacle. Stress-induced premature senescence as alternative toxicological method for testing the long-term effects of molecules under development in the industry. Biogerontology, 1 (2), 177-181, 2000.
