Publications
Selected papers
1. Ito, T., Ando, H., Suzuki, T., Ogura, T., Hotta, K., Imamura, Y., Yamaguchi, Y. and Handa, H. Identification of a primary target of thalidomide teratogenicity. Science, 327, 1345-1350, 2010.
2. Park, S. Y., Handa, H. and Sandhu, A. Magneto-optical biosensing platform based on light scattering from self-assembled chains of functionalized rotating magnetic beads. Nano Lett., 10, 446-451, 2010.
3. Chen, Y., Yamaguichi, Y., Tsugeno, Y., Yamamoto, J., Yamada, t., Nakamura, M., Hisatake, K. and Handa, H. DSIF, the Paf1 complex, and Tat-SF1 have non-redundant, cooperative roles in RNA polymerase II elongation. Genes Dev., 23, 2765-2777, 2009.
4. Sakamoto, S., Kabe, Y., Hatakeyama, M., Yamaguchi, Y. and Handa, H. Development of application of high-performance affinity beads: toward chemical biology and drug discovery (review). Chem. Rec., 9, 66-85, 2009.
5. Kang, J., Gemberling, M., Nakamura, M., Whitby, F. G., Handa, H., Fairbrother, W. and Tantin, D. A general mechanism for transcription regulation by Oct1 and Oct4 in response to genotoxic and oxidative stress. Genes Dev., 23, 208-222, 2009.
6. Narita, T., Yung, T. M. C., Yamamoto, J., Tsuboi, Y. Tanabe, H., Tanaka, K., Yamaguchi, Y and Handa, H. NELF interacts with CBC and participates in 3’-end processing of replication-dependent histone mRNAs. Mol Cell, 26, 349-365, 2007.
7. Yamada, T., Yamaguchi, Y., Inukai, N., Kamijo, S., Mura, T. and Handa, H. P-TEFb-mediated phosphorylation of the hSpt5 C-terminal repeats is critical to processive transcription elongation. Mol. Cell, 21, 227-237, 2006.
8. Wang, G., Balamotis, M. A., Stevens, J.L., Yamaguchi, Y., Handa, H. and Berk, A. A. Mediator requirement for both recruitment and postrecruitment steps in transcription initiation. Mol. Cell, 5, 683-694, 2005.
9. Shimizu, N., Ouchida, R., Yoshikawa, N., Hisada, T., Watanabe, H., Okamoto, K., Kusuhara, M., Handa, H., Morimoto, C and Tanaka, H. HEXIM1 forms a transcriptionally abortive complex with glucocorticoid receptor without involving 7SK RNA and positive transcription elongation factor b. Proc. Natl. Acad. Sci. USA, 102, 8555-8560, 2005.
10. Aiyar, S.E., Sun, J-L., Blair, L.A., Moskaluk, A.C., Lv, Y., Ye, O-N., Yamaguchi., Y, Mukherjee., A, Re., D-M., Handa, H. and Li, R. Attenuation of estrogen receptor α-mediated transcription through estrogen-stimulated recruitment of a negative elongation factor. Genes Dev., 18, 2134-2146, 2004.
11. Mandal. S. S, Chu, C., Wada, T., Handa, H., Shatkin, J.A. and Reinberg, D. Functional interactions of RNA-capping enzyme with factors that positively and negatively regulate transcription during promoter escape. Proc. Natl. Acad. Sci. USA, 101, 7572-7577, 2004.
12. Wu, C-H., Yamaguchi, Y., Benjamin, L., Horvat-Gordon, M., Washinski, J., Enerly, E., Lambertsson, A., Handa, H. and Gilmour, D. NELF and DSIF are implicated in causing promoter proximal pausing on the hsp70 promoter in Drosophila. Genes Dev., 17, 1402-1414, 2003.
13. Yamaguchi, Y., Filipovska, J., Yano, K., Furuya, A., Inukai, N., Narita, T., Wada, T., Sugimoto, S., Konarska, M.M. and Handa, H. Stimulation of RNA polymerase II elongation by hepatitis delta antigen. Science, 293, 124-127, 2001.
14. Guo, S., Yamaguchi, Y., Schilbach, S., Wada, T., Lee, J., Goddard, A., French, D., Handa, H. and Rosenthal, A. A regulator of transcriptional elongation controls vertebrate neuronal development. Nature, 408, 366-369, 2001.
15. Shimizu, N., Sugimoto, K., Tang, J., Nishi, T., Sato, I., Hiramoto, M., Aizawa, S., Hatakeyama, M., Ohba, R., Hatori, H., Yoshikawa, T., Suzuki, F., Oomori, A., Watanabe, H., Tanaka, H., Kawaguchi, H. and Handa, H. High-performance affinity beads for identifying drug receptors. Nature Biotechnol., 18, 877-881, 2000.
16. Wada, T., Orphanides, G., Hasegawa, J., Kim, D-K., Shima, D., Yamaguchi, Y., Fukuda, A., Hisatake, K., Oh, S., Reinberg, D. and Handa, H. FACT relieves DSIF/NELF-mediated inhibition of transcriptional elongation and reveals functional differences between P-TEFb and TFIIH. Mol. Cell, 5, 1067-1072, 2000.
17. Yamaguchi, Y., Takagi, T., Wada, T., Yano, K., Furuya, A., Sugimoto, S., Hasegawa, J. and Handa, H. NELF, a multiple complex containing RD, cooperates with DSIF to repress RNA plymerase II elongation. Cell, 97, 41-51, 1999.
