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Jeng-Jong Hwang

Biomedical Imaging and Radiological Sciences
National Yang-Ming University

Publications

1. Lin FJ, Leu MY, Hwang JJ (1989): Determination of possible doses to the gonads or fetus in pregnant patients during radiation therapy. J Formos Med Assoc, 98(5), 462-468.
2. Hwang JJ, Hsia SM, Jirtle RL (1993): Induction of sister chromatid exchange and micronuclei in primary cultures of rat and human hepatocytes. Mutation Res, 286, 123-133.
3. Hwang JJ* (1994): Genetic effect induced by ionizing radiation. INER Quarterly, 10, 26-33.
4. Hwang JJ* (1995): Biological effects induced by very low dose ionizing radiation. 88th Conference of Fomosan Medical Association, 174-178.
5. Hwang JJ*, Wang HS and Lin FJ (1996): Cell, tissue, tumor kinetics and its clinical applications. Therapeu Radiol Oncol, 3, 265-274.
6. Yen TC, Hwang JJ*, Wang HS (1996): Chromosomal aberrations induced in human lymphocytes after iodine-131 treatment for diagnosis of hyperthyroidism. J Biomed Lab Sci, 8, 91-96.
7. King KL, Hwang JJ, Chau GY, Tsay SH, Chi CW, Lee TG (1998): Ki-67 expression as a prognostic marker in patients with hepatocellular carcinoma. J Gastroen Hepatol, 13, 273-279.
8. Hwang JJ*, Chen HE, Tzeng WF, Lin GL, Deng WP, Lin FJ (1998): The effects of menadione alone or combined with ionizing radiation on human hepatoma cells. Therapeut Radiol Oncol, 5, 101-109.
9. Hwang JJ*, Lin GL, Sheu SC, Lin FJ (1999): Effect of ionizing radiation on liver mitochondrial respiratory functions in mice. Chinese Med J, 112(4), 340-344.
10. Deng WP, Hwang JJ, Lin GL (1999): Radiation-induced gene regulation. Therapeut Radiol Oncol, 5, 221-232.
11. Hwang JJ, Yen TC, Hsieh BT, Ting G (1999): Application of macroautoradiography and instantimage in radiopharmaceutical research. J Radioan Nucl Ch, 241, 581-587.
12. Chang WP, Hsieh WH, Chen DP, Lin YP, Hwang JS, Hwang JJ (1999): Change in centromeric and acentromeric micronucleus frequencies in human populations after chronic radiation exposure. Mutagenesis, 14(4), 427-432.
13. Hwang JJ*, Chen PY, Deng WP, Hwang JY, Lin GL, Lin FJ (1999): Combined treatment effect of 5-fluorouracil with ionizing radiation on human colorectal carcinoma cells. Therapeut Radiol Oncol, 6, 73-82.
14. Hwang JJ* (2001): The application of radiobiology in the clinical radiation oncology. Gamma, 32, 3-9.
15. Chen SK, Tsai MH, Lin CH, Hwang JJ, Chang WP (2001): Determination of 8-oxoguanine in individual cell nucleus of -irradiated mammalian cells. Radiat Res, 155, 832-836.
16. Hsieh WA, Lucas JN, Hwang JJ, Chan CC, Chang WP (2001): Biodosimetry using chromosomal translocations measured by FISH in a population chronically exposed to low dose-rate 60Co -irradiation. Int J Radiat Biol 77, 797-804.
17. Chen FD, Wu MC, Wang HE, Hwang JJ, Hong CY, Huang YT, Yen SH, Ou YH (2001): Sensitization of a tumor, but not a normal tissue, to the cytotoxic effect of ionizing radiation using panax notoginseng extract. Amer J Chin Med 29(3-4), 517-524.
18. Wong YK, Tang KT, Wu JC, Hwang JJ, Wang HS (2001): Stimulation of hyaluronan synthesis by interleukin-1 involves activation of protein kinase C II in fibroblasts from patients with Graves’ ophthalmopathy. J Cell Biochem 82, 58-67.
19. Chan JYH, Chen LK, Chang JF, Ting HM, Goy C, Chen JL, Hwang JJ, Chen FD, Chen DJ, Ngo FQH (2001): Differential gene expression in a double-strand-break repair mutant XRS-5 defective in Ku80: analysis by cDNA microarray. J Radiat Res, 42, 371-385.
20. Hwang JJ*, Liao MH, Yen TC, Pan WHT, Wey SP, Chen JC, Ting G (2002): Biodistribution study of [99mTc]TRODAT-1 alone or combined with other dopaminergic drugs in mice with macroautoradiography. Appl Radiat Isotopes, 57, 35-42.
21. Jen MH, Hwang JJ, Yang JY, Nabyvanets YB, Hsieh WA, Tsai MH, Guo SD, Chang WP (2002): Micronuclei and nuclear anomalies in urinary exfoliated cells of subjects in radionuclides-contaminated regions. Mutat Res, 520, 39-46.
22. Hsieh WA, Lin YA, Ni C, Hwang JJ, Chang WP (2002): Evaluation of the frequencies of chromosomal aberrations in a population exposed to prolonged low dose-rate 60Co -irradiation. Int J Radiat Biol, 78, 625-633.
23. Lin KJ, Ye XX, Yen TC, Wey SP, Tzen KY, Ting G, Hwang JJ* (2002):Biodistribution study of [123I]ADAM in mice: correlate to whole body autoradiography. Nucl Med Biol, 29, 669-676.
24. Hwang JJ*, Liao MH, Ngo FQH (2002): Autoradiography and its image application in radiopharmaceutical research. J Radiologic Tech, 26, 1-11.
25. Dong SL, Chu TC, Lee JS, Lan GY, Wu TH, Yeh YH, Hwang JJ* (2002): Estimation of mean glandular dose from monitoring breast entrance skin air kerma using high sensitivity metal oxide semiconductor field effect transistor (MOSFET) dosimeter system in mammography. Appl Radiat Isotopes, 57, 791-799.
26. Wang HE, Liao AH, Chang PF, Chen FD, Chen JC, Hwang JJ* (2002) [18F]BPA (4-borono-2-[18F]fluoro- L-phenyla;anine-fructose), a boron-containing drug designed specificly for boron neutron capture therapy. Research and Development in Neuron Capture Therapy, Proceeding of the 10th International Congress on Neuron Capture Therapy; 909-912.
27. Chen HW, Lai KC, Lin FJ, Lai YL, Hwang JJ* (2003): Increase in HPRT mutation frequency in tongue cancer patients after radiotherapy: report of two cases. J Health Science, 5, 185-193.
28. Wang HE, Liao AH, Deng WP, Chang PF, Chen FD, Liu RS, Chen JC, Lee JS, Hwang JJ* (2004): Evaluation of 4-borono-2-[18F]fluoro-L-phenylalanine-fructose as a probe for BNCT in glioma-bearing rat model. J Nucl Med, 45, 302-308.
29. Ye XX, Chen JC, Liu RS, Wey SP, Lee JS, Chen CC, Fu YK, Ting G, Hwang JJ* (2004): Microautoraduography of [123I]ADAM in mice treated with fluoxetine and serotonin reuptake inhibitors. Nucl Med Biol, 31(5), 557-563.
30. Deng WP, Yang WK, Lai WF, Liu RS, Hwang JJ, Yang DM, Fu YK, Wang HE (2004): A new simplified method of preparation and radiolabeling of FIAU for in vivo imaging of herpes simplex virus type 1 thymidine kinase gene expression. Eu J Nucl Med, 31, 99-109.
31. Lin KJ, Yen TC, Wey SP, Hwang JJ, Ye XX, Tzen KY, Chen JC (2004): Characterization of the binding sites for 123I-ADAM and the relationship to the serotonin transporter in rat and mouse brains using quantitative autoradiography. J Nucl Med, 45, 673-681.
32. Chang YF, Hwang JJ* (2004): Microarray biotechnology. Science Development, 381, 34-41.
33. Ye XX, Hwang JJ, Shieh JF, Chen JC, Chou YT, Tu KY, Wey SP, Ting G (2004): In Vivo Quantification of bound [123I]ADAM to serotonin transporters in the brains of rabbits by SPECT. Nucl Med Biol, 31, 995-1003.
34. Wang HE, Wu SY, Chang CW, Liu RS, Hwang LC, Lee TW, Chen CJ, Hwang JJ* (2005): Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model. Nucl Med Biol, 32, 367-375.
35. Chen HW, Chang YC, Lai YL, Chen YJ, Huang MJ, Leu YS, Fu YK, Wang LW, Hwang JJ* (2005): Plasma TGF-β1 levels in nasopharyngeal carcinoma patients treated with concurrent chemo-radiotherapy, Jpn J Clin Oncol, 35, 427-432.
36. Hsieh CH, Chen YF, Cheng FD, Hwang JJ, Chen JC, Liu RS, Kai JJ, Chang CW, Wang HE (2005): Evaluation of pharmacokinetics of 4-borono-2-18F-fluoro-L-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperosmolar blood-brain-barrier disruption. J Nucl Med, 46, 1858-1865.
37. Ding LH, Shingyoji M, Chen F, Hwang JJ, Burma S, Lee C, Cheng J-F, Chen DJ (2005): Gene expression profiles of normal human fibroblasts after exposure to ionizing radiation: A comparative study of low and high doses. Radiat Res, 164, 17-26.
38. Lin CT, Chen FD, Fu YK, Wang HE, Hwang JJ, Chen JC, Deng WP, Huang WS, Hwang LH, Chang CW, Liu RS (2005): In vivo gene expression imaging by using plasmid vector containing HSV1-tk genes. Ann Nucl Med Sci, 18, 85-92.
39. Lee WC, Hwang JJ*, Tseng YL ,Wang HE, Chang YF, Lu YC, Ting G, Whang-Peng J, Wang SJ (2006): Therapeutic efficacy evaluation of 111In-VNB-liposome on human colorectal adenocarcinoma HT-29/luc mouse xenografts. Nucl Instrum Meth A, 569, 497-504.
40. Wang HE, Yu HM, Lu YC, Heish NN, Tseng YL, Huang KL, Chuang KT, Chen CH, Hwang JJ, Lin WJ, Wang SJ, Ting G, Peng JW, Deng WP (2006): Internal radiotherapy and dosimetric study for 111In/177Lu-pegylated liposomes conjugates in tumor-bearing mice. Nucl Instrum Methods Phys Res A, 569, 533-537.
41. Yu HM, Yeh HP, Chang TK, Huang KL, Chuang KT, Liu RS, Wang SJ, Hwang JJ, Chi KH, Chen FD, Lin WJ, Chen CH, Wang HE (2006): Improved targeting of 5-[125I/131I]iodo-2’-deoxyuridine to rat hepatoma by using lipiodol emusion. Nucl Instrum Meth A, 569, 538-542.
42. Deng WP, Wu CC, Lee CC, Yang WK, Wang HE, Liu RS, Wei HJ, Gelovani J, Hwang JJ, Yang DM, Fu YK, Wu CW (2006): Serial in vivo imaging of the lung metastases model and gene therapy using HSV1-tk and ganciclovir. J Nucl Med, 47, 877-884.
43. Hwang JJ*, Wang HE, Fang HY, Chen FD, Liu RS, Ngo FQH (2006): Biodistribution of dual radiosensitizers [131I]iododeoxyuridine and [18F]misonidazole in KHT sarcoma-bearing mice: correlation with whole-body autoradiography. Int J Cancer Mol, 2, 37-43.
44. Deng WP, Chao WM, Lai WF, Sun C, Chung CY, Wu CC, Lin IH, Hwang JJ, Wu CH, Chiu WT, Chen CY, Redpath JL (2006): Correction of malignant behavior of tumor cells by traditional Chinese herb medicine through a restoration of p53. Cancer Lett, 233, 315-327.
45. Wang HE, Yu HM, Liu RS, Lin M, Gelovani JG, Hwang JJ, Wei HJ, Deng WP (2006): Molecular imaging with 123I-FIAU, 18F-FudR, 18F-FET, and 18F-FDG for monitoring Herpes Simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer. J Nucl Med, 47, 1161-1171.
46. Hsieh CH, Liu HM, Hwang JJ, Wang HE, Kai JJ, Chen FD (2006): A simple model for quantification of the radiobiological effectiveness of the 10B(n, )7Li capture reaction in BNCT. Appl Radiat Isotopes, 64, 306-314.
47. Chang YF, Lin YY, Wang HE, Liu RS, Pang F, Hwang JJ* (2007): Monitoring of tumor growth and metastasis potential in MDA-MB-435s-tk/luc human breast cancer xenografts. Nucl Instrum Meth A, 571, 155-159.
48. Chen CC, Hwang JJ*, Ting G, Tseng YL, Wang SJ, Whang-Peng J (2007): Temporal Monitoring and Quantitative Assessment of Tumor Burden Growth Using In Vivo Bioluminescence Imaging. Nucl Instrum Meth A, 571, 437-441.
49. Su YC, Chuang KH, Wang YM, Cheng CM, Lin SR, Wang JY, Hwang JJ, Chen BM, Chen KC, Rofler S, Cheng TL (2007): Gene expression imaging by enzymatic catalysis of a fluorescent probe via membrane-anchored -gluculonidase. Gene Therapy, 14, 565-574.
50. Liao AH, Hwang JJ, Li CH, Cheng WF, Li PC (2007): Noninvasive tumor imaging with high-frequency ultrasound and microPET in small animals. Ultrasonic Imaging, 29, 182-194.
51. Chen HW, Chang YC, Chen YJ, Huang MJ, Leu YS, Chang GH, Hwang JJ* (2008): Epstein-Barr virus infection and plasma transforming growth factor-1 levels in head and neck cancers. Acta Oto-Laryngologica, 128(10):1145-1151.
52. Hsieh CH, Chen FD, Wang HE, Hwang JJ, Chang CW, Lee YJ, Gelovani JG, Liu RS (2008): Generation of destabilized herpes simplex virus type 1 thymidine kinase as transcription reporter for positron emission tomography reporter systems in molecular-genetic imaging. J Nucl Med, 49, 142-150.
53. Chow TH, Lin YY, Hwang JJ*, Wang HE, Tseng YL, Pang VF, Wang SJ, Whang-Peng J, Ting G (2008): Diagnostic and therapeutic evaluation of 111In-vinorelbine liposomes in a human colorectal carcinoma HT-29/luc-bearing animal model. Nucl Med Biol, 35, 623-634.
54. Lee YJ, Tsai CH, Hwang JJ, Chiu SJ, Sheu TJ, Keng PC (2009): Involvement of a p53-independent and post-transcriptional up-regulation for p21WAF/CIP1 following destabilization of the actin cytoskeleton. Intl J Oncol, 34:581-589.
55. Liu RS, Hsieh YJ, Ke CC, Chen FD, Hwu L, Wang FH, Hwang JJ, Chi CW, Lee CH, Yeh SH (2009): Specific activation of sodium/iodide symporter gene in hepatoma using alpha-fetoprotein promoter combined with hepatitis B virus enhancer (EIIAPA). Anticancer Res, 29:211-222.
56. Chow TH, Lin YY, Hwang JJ*, Wang HE, Tseng YL, Wang SJ, Liu RS, Lin WJ, Yang CS, Ting G (2009): Improvement of biodistribution and therapeutic index via increase of polyethylene glycol on drug-carrying liposomes in an HT-29/luc xenografted mouse model. Anticancer Res, 29:2111-2120.
57. Ma KH, Huang WS, Guo YY, Peng CJ, Liu RS, Hwang JJ, Liu JC, Chen HJ, Shiue CY (2009): Validation of 4-[18F]-ADAM as a SERT imaging agent using micro-PET and autoradiography. Neuroimage, 45:687-693.
58. Lin YY, Li JL, Chang CH, Lu YC, Hwang JJ, Tseng YL, Lin WJ, Ting G, Wang HE (2009): Evaluation of pharmacokinetics of 111In-labeled VNB-liposomes after intraperitoneal and intravenous administration in a tumor/ascites mouse model. Cancer Biother Radio, 24, 453-460.
59. Chow TH, Lin YY, HwangJJ*, Wang HE, Tseng YL, Pang VF, Liu RS, Lin WJ, Yang CS, Ting G (2009): Therapeutic efficacy evaluation of 111In-labeled pegylated liposomal vinorelbine in murine colon carcinoma with multimodalities of molecular imaging. J Nucl Med, 50, 2073-2081.
60. Lin YC, Chen HW, Kuo YC, Chang YF, Hwang JJ* (2010): Therapeutic efficacy evaluation of curcumim on human oral squamous cell carcinoma xenograft using multimodalities of molecular imaging. Am J Chin Med, 38, 343-358.
61. Liao AH, Chou FI, Kuo YC, Chen HW, Kai JJ, Chang CW, F.D. Chen FD, Hwang JJ* (2010): Biodistribution of phenylboric acid derivative entrapped lipiodol and 4-borono-2-18F-fluoro-L-phenylalanine-fructose in GP7TB liver tumor bearing rats for BNCT. Appl Radiat Isotopes, 68, 422-426.
62. Chuang HY, Chang YF, Hwang JJ* (2011): Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal. Biomed Phamacother, 45:100-110.
63. Kuo YC, Chiu YM, Shih WP, Yu HW, Chen CW, Wong PF, Lin WC, Hwang JJ* (2011): Volumetric intensity-modulated Arc (RapidArc) therapy for primary hepatocellular carcinoma: comparison with intensity-modulated radiotherapy and 3-D conformal radiotherapy. Rad Oncol, 6:76-84.
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Member since July 12, 2011
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