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Assistant Investigator/Professor

- (3151698)

Assistant Investigator/Professor, Division of Thoracic Surgery, Massachusetts General Hospital


The Division of Thoracic Surgery at Massachusetts General Hospital seeks candidates for a research faculty position at the rank of Assistant Professor within an NIH funded surgical division. The position requires a highly motivated scientist with expertise in molecular biology, and an interest in cancer genomics and/or and immuno-oncology. Projects are molecular and translational in scope requiring a strong basic science background. The candidate will be responsible for experimental design and will direct cutting-edge research with a focus on mechanisms of action and clinical translation primarily in lung and esophageal cancers. Current basic science expertise in the division includes nanotechnology, a large variety of ex vivo and in vivo tumor models, viral gene therapy, targeted in vivo imaging and translational clinical oncology trials. This position offers outstanding scholarly and scientific resources in a collegial and collaborative environment including Harvard-affiliated teaching hospitals and research institutions throughout Boston. There is a strong emphasis on mentoring for successful grant writing in both technical and clinical applications by two NIH funded investigators that form a collaborative team focused on therapeutic drug-delivery. The position includes an academic appointment through Harvard Medical School, salary support, and two years of initial research funding and resources to allow the candidate to establish an independent research career path, with the expectation of achieving independent funding in the future.


Teaching Requirements: The individual will have a role in teaching laboratory research techniques to MDs and PhD fellows, and assist with their experimental designs. The individual is expected to provide leadership and expertise to team members in the area of oncology, cancer/tumor biology, and to work with surgeon-investigator colleagues within the division to progress divisional laboratory initiatives.

Research Requirements: The individual will serve as a key source for molecular projects in oncology and immunology. An ability to design and interpret data using in vitro and in vivo oncology models is required, as is experience in the development of relevant oncology models using new molecular technologies to engineer cell lines or work with primary tumor cells.

Specific Requirements

Interest in personal career development and positive visibility within the scientific community Designs and performs studies to examine molecular and biochemical mechanisms of action in vitro Expertise in murine tumor models (genetically engineered or syngeneic) Experience in murine and human cancer biology with tumor microenvironment (TME) remodeling Ability to investigate the molecular biology of cancer in target areas such as oncogenic signaling, stromal biology, and cancer genetics. Experience in immuno-oncology is a plus. Strong understanding and expertise with current and cutting-edge genetic manipulation models such as with CRISPRs, TALENs, ZFNs, or miRNA profiling and the many types of arrays is required Experience with bioinformatics analysis of RNAseq, nucseq, and other high throughput genomic analyses Experience with functional immunologic assays measuring cellular activation, cytokine release, proliferation, and killing Multi-parameter flow cytometry and proficiency in FACS data analysis is a plus but not required Willingness to work with colleague surgeon-investigators in the division to support collaborative laboratory initiatives

Administrative Requirements: The individual must have organizational and leadership skills in addition to an ability to read, analyze, and interpret common scientific and technical journals. The individual will play an important role as senior management of the team and must have a desire to initiate and write grant proposals (fellowships, foundations, NIH etc.) as well as scientific publications, and must be able to effectively present scientific information.


The individual must have a Ph.D., M.D., or M.D., Ph.D. and have demonstrated a strong research record and a commitment to teaching, mentoring, and training. Grant writing skills are a plus, but strong mentorship in writing is available. Fluency in English is required.

For consideration, please provide a curriculum vitae, statement of research (up to 5 pages, including a summary of previous research accomplishments and future research interests), teaching statement, and PDFs of up to 5 publications. Successful candidates are also required to submit the names and contact information for three to five references before securing the position. Complete applications should be received no later than September 1, 2021.

EEO Statement Massachusetts General Hospital is an Equal Opportunity Employer. By embracing diverse skills, perspectives and ideas, we choose to lead. Applications from protected veterans and individuals with disabilities are strongly encouraged.

Primary Location MA-Boston-MGH Main Campus Other Locations MA-Boston-MGH 185 Cambridge Work Locations MGH Main Campus 55 Fruit Street Boston 02114 Job Technician/Technologist/Scientist Organization Massachusetts General Hospital(MGH) Schedule Full-time Standard Hours 40 Shift Day Job Employee Status Regular Recruiting Department MGH Thoracic Surgery Job Posting Apr 7, 2021

Massachusetts General Hospital(MGH)

Posted: July 11, 2021
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